PMID: 9426088Jan 13, 1998Paper

Annual variability in methacholine responsiveness in nonasthmatic working adults

The European Respiratory Journal
W S BeckettS T Weiss

Abstract

Change in airway responsiveness is used frequently as a clinical as well as an epidemiological tool. Changes in airway responsiveness can be superior to other measures of lung function in that they are more sensitive indicators of an environmental effect. However, normal variation in test results must be defined before change can be interpreted. To characterize annual variability in airways responsiveness, we administered a high-dose methacholine challenge at 1 yr intervals for up to 4 yrs to 105 healthy, nonasthmatic working subjects. Using this high-dose protocol, the majority of tests (83%) produced at least a 20 % fall in forced expiratory volume in one second (FEV1), allowing standard calculation of the provocative dose of methacholine causing a 20% fall in FEV1 (PD20). An annual change in methacholine responsiveness by one or more doubling doses was seen in at least 30% of subjects each year. The components of variance of airways responsiveness measures were estimated to allow direct comparison of within-subject and between-subject variability. The within-subject variability in PD20, was markedly greater than the comparable within-subject variability in FEV1. Level of FEV1 and age were both significant determinants of met...Continue Reading

Citations

Jul 16, 2005·American Journal of Respiratory and Critical Care Medicine·Susan ChinnPeter G Burney
Nov 23, 2015·Occupational Medicine·J Borak, R Y Lefkowitz
Aug 15, 2008·American Journal of Industrial Medicine·David J Hewitt
Mar 31, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R GaleraF García-Río
Sep 10, 2013·Respiratory Physiology & Neurobiology·Satu StrengellSam Bayat
Jan 23, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Oliver J PriceJames H Hull
Oct 11, 2013·Scientific Reports·Anton LopertMatjaž Fležar
Sep 6, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Akshay SoodPatricia Hopkins-Price

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