ANO7 is associated with aggressive prostate cancer.

International Journal of Cancer. Journal International Du Cancer
Elina KaikkonenJohanna Schleutker

Abstract

Prostate cancer is one of the most common and heritable human cancers. Our aim was to find germline biomarkers that can predict disease outcome. We previously detected predisposing signals at 2q37, the location of the prostate specific ANO7 gene. To investigate, in detail, the associations between the ANO7 gene and PrCa risk and disease aggressiveness, ANO7 was sequenced in castration resistant tumors together with samples from unselected PrCa patients and unaffected males. Two pathogenic variants were discovered and genotyped in 1769 patients and 1711 unaffected males. Expression of ANO7 vs. PrCa aggressiveness was investigated. Different databases along with Swedish and Norwegian cohorts were used for validation. Case-control and aggressive vs. nonaggressive association analyses were performed against risk and/or cancer aggressiveness. The ANO7 mRNA level and patient survival were analyzed using expression data from databases. Variant rs77559646 showed both risk (OR 1.40; p = 0.009, 95% CI 1.09-1.78) and association with aggressive PrCa (Genotype test p = 0.04). It was found to be an eQTL for ANO7 (Linear model p-values for Finnish patients p = 0.009; Camcap prostate tumor p = 2.53E-06; Stockholm prostate tumor cohort p = 1.5...Continue Reading

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Citations

Mar 22, 2019·Cancers·Karl KunzelmannRainer Schreiber
Jul 9, 2020·The Application of Clinical Genetics·Erin L CrowgeyTodd E Druley
Mar 17, 2020·Cancer Biomarkers : Section a of Disease Markers·Elina KaikkonenJohanna Schleutker
Oct 30, 2020·International Journal of Molecular Sciences·Xiaogang ZhangWillem Stoorvogel

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Methods Mentioned

BETA
Genotyping
Assay

Software Mentioned

Matrix eQTL
Survival
Package “ Survival
R

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