Anodal transcranial direct current stimulation (tDCS) over supplementary motor area (SMA) but not pre-SMA promotes short-term visuomotor learning

Brain Stimulation
Henning VollmannPatrick Ragert

Abstract

Non-invasive brain stimulation such as transcranial direct current stimulation (tDCS) has been shown to modulate cortical excitability and thereby influencing motor behaviour and learning. While there is increasing knowledge about the importance of the primary motor cortex (M1) in short- and long-term motor skill learning, little is known about the role of secondary motor areas such as the supplementary and pre-supplementary motor area (SMA/pre-SMA) especially in short-term motor performance. Since SMA but not pre-SMA is directly connected to M1, we hypothesize that anodal tDCS over SMA but not pre-SMA will facilitate visuomotor learning. We applied anodal tDCS (tDCS(anodal)) over left SMA, pre-SMA or M1 (n=12 in each group) while subjects performed a visuomotor pinch force task (VPFT) with their right hand and compared VPFT performance relative to sham (tDCS(sham)). For the first time, we could show that apart from tDCS(anodal) over left M1 also SMA but not pre-SMA stimulation promotes short-term improvements in visuomotor learning relative to tDCS(sham). Our findings provide novel evidence about the role of SMA in short-term visuomotor performance. This knowledge might be beneficial in developing hypothesis-driven clinical st...Continue Reading

References

Jan 1, 1991·Experimental Brain Research·M P DeiberR S Frackowiak
Dec 1, 1993·The Journal of Comparative Neurology·G LuppinoG Rizzolatti
Mar 15, 1994·The Journal of Comparative Neurology·M T LuP L Strick
Sep 30, 1998·The European Journal of Neuroscience·V VorobievG Luppino
Mar 13, 2001·Journal of Cognitive Neuroscience·S T GraftonD B Willingham
May 16, 2002·Experimental Brain Research·Hartmut Leuthold, Ines Jentzsch
Aug 17, 2002·Cerebral Cortex·Marcel Brass, D Yves von Cramon
Sep 17, 2002·Experimental Brain Research·Scott T GraftonRichard B Ivry
Jul 28, 2004·NeuroImage·Tor D WagerSusan Reading
Oct 30, 2004·The Journal of Physiology·Kaoru MatsunagaJohn C Rothwell
Jan 7, 2005·Brain : a Journal of Neurology·Friedhelm HummelLeonardo G Cohen
Jan 26, 2005·Current Biology : CB·Parashkev NachevMasud Husain
May 30, 2006·Journal of Physiology, Paris·Ulrike Halsband, Regine K Lange
Jan 26, 2007·Journal of Neurophysiology·M A NitscheW Paulus
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dalila AkkalPeter L Strick
Sep 13, 2008·Cerebral Cortex·Natalia S LawrenceMary L Phillips
Oct 10, 2008·Nature Reviews. Neuroscience·Parashkev NachevMasud Husain
Oct 15, 2008·NeuroImage·Chiao-Yun ChenChi-Hung Juan
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Janine ReisJohn W Krakauer
Mar 19, 2009·Journal of Neuroengineering and Rehabilitation·Nadia BologniniFelipe Fregni
May 9, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pedro Cavaleiro MirandaMark Hallett
Sep 3, 2009·The Journal of Physiology·Masashi HamadaYoshikazu Ugawa
Oct 1, 2009·The European Journal of Neuroscience·C J StaggH Johansen-Berg
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudia DanielmeierMarkus Ullsperger
Nov 15, 2011·Neuron·Eran Dayan, Leonardo G Cohen

❮ Previous
Next ❯

Citations

Feb 13, 2016·Developmental Neurorehabilitation·Adriana Costa-RibeiroKátia Monte-Silva
Feb 6, 2016·Annals of the New York Academy of Sciences·Katharine DunlopJonathan Downar
Mar 29, 2016·Physiology & Behavior·Tércio Apolinário-SouzaGuilherme Menezes Lage
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elisabeth KaminskiPatrick Ragert
Jun 5, 2015·Frontiers in Neuroscience·Reiko MatsushitaRobert J Zatorre
Dec 1, 2012·NeuroImage·Robert M HardwickSimon B Eickhoff
Jan 1, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Holger Hill
Dec 15, 2016·Frontiers in Neuroscience·Suman DasOpher Donchin
Oct 25, 2016·Journal of the International Neuropsychological Society : JINS·Michael DoppelmayrFabian Steinberg
Jan 5, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Florian LammersGeorg Winterer
Jun 13, 2020·Journal of Cognitive Neuroscience·Til Ole Bergmann, Gesa Hartwigsen
Apr 25, 2020·Frontiers in Human Neuroscience·Oliver Seidel-Marzi, Patrick Ragert
Sep 23, 2020·Cerebral Cortex·Trevor StewardBen J Harrison
Jan 10, 2017·Frontiers in Psychology·Claudia AmmannJavier Márquez-Ruiz
Aug 21, 2013·Cerebral Cortex·Janine ReisBrita Fritsch
Feb 25, 2017·Frontiers in Neurology·Stephanie Lefebvre, Sook-Lei Liew
Jul 14, 2020·Journal of Motor Behavior·Juliana Otoni ParmaTércio Apolinário-Souza
Feb 11, 2021·Scientific Reports·E KaminskiP Ragert
Apr 23, 2021·Brain Structure & Function·Stéfanie A TremblayClaudine J Gauthier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.