Anogenital distance in adult women is a strong marker of endometriosis: results of a prospective study with laparoscopic and histological findings

Human Reproduction Open
A CrestaniE Darai

Abstract

Could anogenital distance (AGD) be a non-invasive marker of endometriosis and correlated to the American Society for Reproductive Medicine revised score (r-ASRM) and ENZIAN classifications? Surgically and histologically proven endometriosis is associated with a short AGD in women of reproductive age but not correlated either to the severity or to the location of the disease. AGD is a marker of intrauterine androgen exposure and exposure to oestrogen-like chemicals such as phthalates. Moreover, exposure to endocrine disruptors, such as organochlorine chemicals, is associated with endometriosis. It has been suggested that a short AGD in women is associated with an increased risk of endometriosis based on clinical and ultrasound exams. A prospective cohort study was conducted from January 2018 to June 2019 in a tertiary-care centre including 168 adult women undergoing pelvic surgery. Of the 168 women included, 98 patients had endometriosis (endometriosis group) and 70 did not (non-endometriosis group). An operator (not the surgeon) measured the distance from the clitoral surface to the anus (AGD-AC) and from the posterior fourchette to the anus (AGD-AF) before surgery using a millimetre accuracy ruler. Endometriosis was diagnosed ...Continue Reading

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Citations

Feb 25, 2021·Human Reproduction Open·A CrestaniE Darai
Apr 16, 2021·Evolution, Medicine, and Public Health·Natalie DinsdaleBernard Crespi
Jul 24, 2021·Evolutionary Applications·Natalie L Dinsdale, Bernard J Crespi

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Methods Mentioned

BETA
biopsy
imaging techniques

Software Mentioned

Stata

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