Anolis carolinensis as a model to understand the molecular and cellular basis of foveal development

Experimental Eye Research
Naif S SannanCheryl Y Gregory-Evans

Abstract

The fovea is an anatomical specialization of the central retina containing closely packed cone-photoreceptors providing an area of high acuity vision in humans and primates. Despite its key role in the clarity of vision, little is known about the molecular and cellular basis of foveal development, due to the absence of a foveal structure in commonly used laboratory animal models. Of the amniotes the retina in birds of prey and some reptiles do exhibit a typical foveal structure, but they have not been studied in the context of foveal development due to lack of availability of embryonic tissue, lack of captive breeding programs, and limited genomic information. However, the genome for the diurnal bifoveate reptile species Anolis carolinensis (green anole) was recently published and it is possible to collect embryos from this species in captivity. Here, we tested the feasibility of using the anole as a model to study foveal development. Eyes were collected at various stages of development for histological analysis, immunofluorescence, and apoptosis. We show that at embryonic stage (ES) 10 there is peak ganglion cell density at the incipient central foveal region and a single row of cone photoreceptor nuclei. At ES17 the foveal pi...Continue Reading

References

Jan 1, 1985·Vision Research·R A BoneS L Tarsis
Mar 22, 1974·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M L Beauchemin
Nov 1, 1984·The Journal of Comparative Neurology·R W Young
Jan 1, 1981·Brain, Behavior and Evolution·K V Fite, B C Lister
Apr 29, 1998·Progress in Neurobiology·J M ProvisB Dreher
Apr 14, 1999·The Journal of Physiology·T P WilliamsJ P Webbers
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dror SharonThaddeus P Dryja
Jun 14, 2002·Progress in Retinal and Eye Research·Billy R Wooten, Billy R Hammond
Nov 24, 2004·The International Journal of Developmental Biology·Elena VecinoMónica García
Aug 5, 2005·Development·Lidia Matter-SadzinskiJean-Marc Matter
May 26, 2006·Investigative Ophthalmology & Visual Science·Catherine Bowes RickmanMichael A Hauser
May 1, 1940·The British Journal of Ophthalmology·K O'Day
Jul 16, 2008·Archives of Ophthalmology·Michael F MarmorJohn S Werner
Aug 16, 2011·Trends in Neurosciences·Andrew D Huberman, Cristopher M Niell
Dec 24, 2011·Visual Neuroscience·Alan D SpringerAnita E Hendrickson
Sep 1, 2012·American Journal of Ophthalmology·Anita HendricksonCynthia A Toth
Jan 5, 2013·Science·Prashant MaliGeorge M Church
May 23, 2014·Investigative Ophthalmology & Visual Science·Melissa A WilkJoseph Carroll
Jul 23, 2015·Investigative Ophthalmology & Visual Science·Helena LeeIrene Gottlob
Feb 16, 2017·The Journal of Comparative Neurology·Mindaugas MitkusAlmut Kelber
Aug 6, 2017·Experimental Eye Research·Nimesh B PatelRonald S Harwerth
Aug 16, 2017·Methods in Molecular Biology·Wataru YamashitaTadashi Nomura
Nov 19, 2017·Progress in Molecular Biology and Translational Science·Ellen Shrock, Marc Güell

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Citations

Aug 3, 2020·Veterinary Ophthalmology·Seokmin GoKangmoon Seo
Jun 15, 2019·Frontiers in Zoology·Carola A M YovanovichTaran Grant
Dec 10, 2020·Scientific Reports·Takefumi SugiyamaTakahisa Furukawa
Apr 19, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ashley M RasysJames D Lauderdale

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