Anomalous fluctuations in sliding motion of cytoskeletal filaments driven by molecular motors: model simulations

The Journal of Physical Chemistry. B
Yasuhiro ImafukuHiizu Nakanishi

Abstract

It has been found in in vitro experiments that cytoskeletal filaments driven by molecular motors show finite diffusion in sliding motion even in the long filament limit [Imafuku, Y. et al. Biophys. J. 1996, 70, 878-886. Noda, N. et al. Biophysics 2005, 1, 45-53]. This anomalous fluctuation can be evidence for cooperativity among the motors in action because fluctuation should be averaged out for a long filament if the action of each motor is independent. In order to understand the nature of the fluctuation in molecular motors, we perform numerical simulations and analyze velocity correlation in three existing models that are known to show some kind of cooperativity and/or large diffusion coefficient, i.e., the Sekimoto-Tawada model [Sekimoto, K.; Tawada, K. Phys. Rev. Lett. 1995, 75, 180], the Prost model [Prost, J. et al. Phys. Rev. Lett. 1994, 72, 2652], and the Duke model [Duke, T. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 2770]. It is shown that the Prost model and the Duke model do not give a finite diffusion in the long filament limit, in spite of the collective action of motors. On the other hand, the Sekimoto-Tawada model has been shown to give a diffusion coefficient that is independent of filament length, but it comes f...Continue Reading

References

Feb 1, 1996·Biophysical Journal·Y ImafukuK Tawada
Apr 18, 1994·Physical Review Letters·J ProstA Ajdari
Sep 25, 1995·Physical Review Letters·F Jülicher, J Prost
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·M BadoualJ Prost
Oct 5, 2002·Journal of Muscle Research and Cell Motility·Karen C VermeulenChristoph F Schmid
Jun 16, 2005·Biophysics·Naoki NodaKatsuhisa Tawada

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Citations

Jul 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Henri PalacciHenry Hess

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