Anomalous origin of the left main pulmonary artery from the ascending aorta associated with DiGeorge syndrome

The American Journal of Cardiology
H DodoR G Williams


We place on record 2 infants with the DiGeorge syndrome and anomalous origin of the left pulmonary artery from the ascending aorta. We postulate that: (1) embryogenesis of anomalous origin of the left pulmonary artery from the ascending aorta might be due to the persistent fifth aortic arch connecting both arterial systems; (2) an anomalous pulmonary artery arising from the ascending aorta is part of the aortic arch abnormality accompanied by normal conotruncal septation; and (3) in the DiGeorge syndrome, cardiac anomalies that originate from the conotruncus or aortic arch, or both, may have the same embryologic mechanisms.


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May 3, 2019·Clinical Pediatrics·Afshin A KhanSong-Gui Yang

Related Concepts

Structure of Fifth Aortic Arch
Shprintzen Syndrome
Embryonic Development
Aortic Arch Structure
Pulmonary Artery Structure
Left Pulmonary Arterial Tree
Congenital Heart Defects
Left Pulmonary Artery

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