Anomalous T2 relaxation in normal and degraded cartilage

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
David A ReiterRichard G Spencer

Abstract

To compare the ordinary monoexponential model with three anomalous relaxation models-the stretched Mittag-Leffler, stretched exponential, and biexponential functions-using both simulated and experimental cartilage relaxation data. Monte Carlo simulations were used to examine both the ability of identifying a given model under high signal-to-noise ratio (SNR) conditions and the accuracy and precision of parameter estimates under more modest SNR as would be encountered clinically. Experimental transverse relaxation data were analyzed from normal and enzymatically degraded cartilage samples under high SNR and rapid echo sampling to compare each model. Both simulation and experimental results showed improvement in signal representation with the anomalous relaxation models. The stretched exponential model consistently showed the lowest mean squared error in experimental data and closely represents the signal decay over multiple decades of the decay time (e.g., 1-10 ms, 10-100 ms, and >100 ms). The stretched exponential parameter αse showed an inverse correlation with biochemically derived cartilage proteoglycan content. Experimental results obtained at high field suggest potential application of αse as a measure of matrix integrity....Continue Reading

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Feb 4, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David A ReiterRichard G Spencer
Jan 26, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David A ReiterRichard G Spencer
Apr 19, 2011·Journal of Magnetic Resonance·Richard L MaginRichard G Spencer
Oct 29, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiang DuGraeme M Bydder

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Citations

Feb 7, 2019·PloS One·Klodiana-Daphne TonaMax C Keuken
Oct 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marcelo V W ZibettiRavinder R Regatte
Nov 15, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Azadeh SharafiRavinder Regatte
Feb 29, 2020·Journal of Magnetic Resonance Imaging : JMRI·Stephan J BredaEdwin H G Oei
May 3, 2020·NMR in Biomedicine·Marcelo V W ZibettiRavinder R Regatte
Mar 27, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shanlin QinViktor Vegh
Jan 7, 2018·Journal of Magnetic Resonance·Sarah E MailhiotJoseph D Seymour
Mar 17, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David A ReiterLuigi Ferrucci
Aug 2, 2021·Journal of Magnetic Resonance·Lixian ZouHaifeng Wang
Nov 6, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marcelo V W ZibettiRavinder R Regatte

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