Anomeric O -Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Simon S ParkJacquelyn Gervay-Hague

Abstract

Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge. With advances in chemical and enzymatic carbohydrate synthesis, the availability of complex carbohydrates is increasing and developing methods for stereoselective conjugation these polar head groups to proteins and lipids is critically important for pharmaceutical applications. The aim of this review is to provide an overview of commonly employed strategies for installing a functionalized linker at the anomeric position as well as examples of further transformations that have successfully led to glycoconjugation to vaccine constructs for biological evaluation as carbohydrate-based therapeutics.

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Citations

Apr 24, 2020·Chemical Communications : Chem Comm·Manuel González-CuestaJosé M García Fernández
Sep 18, 2020·Chemistry : a European Journal·Chun-Wei ChangCheng-Chung Wang
Feb 27, 2021·Angewandte Chemie·Chun-Wei ChangCheng-Chung Wang
Jul 17, 2021·Organic Letters·Mei-Huei LinCheng-Chung Wang

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Methods Mentioned

BETA
Glycosylation
glycosylations

Software Mentioned

ReSET

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