Anopheles immune genes and amino acid sites evolving under the effect of positive selection.

PloS One
Aristeidis ParmakelisJeffrey R Powell

Abstract

It has long been the goal of vector biology to generate genetic knowledge that can be used to "manipulate" natural populations of vectors to eliminate or lessen disease burden. While long in coming, progress towards reaching this goal has been made. Aiming to increase our understanding regarding the interactions between Plasmodium and the Anopheles immune genes, we investigated the patterns of genetic diversity of four anti-Plasmodium genes in the Anopheles gambiae complex of species. Within a comparative phylogenetic and population genetics framework, the evolutionary history of four innate immunity genes within the An. gambiae complex (including the two most important human malaria vectors, An. gambiae and An. arabiensis) is reconstructed. The effect of natural selection in shaping the genes' diversity is examined. Introgression and retention of ancestral polymorphisms are relatively rare at all loci. Despite the potential confounding effects of these processes, we could identify sites that exhibited dN/dS ratios greater than 1. In two of the studied genes, CLIPB14 and FBN8, several sites indicated evolution under positive selection, with CLIPB14 exhibiting the most consistent evidence. Considering only the sites that were co...Continue Reading

References

Jun 20, 1991·Nature·J H McDonald, M Kreitman
Jan 1, 1989·Medical and Veterinary Entomology·A M Feldmann, T Ponnudurai
Jan 1, 1996·Molecular Biology and Evolution·S V Muse
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
May 29, 2002·Molecular Biology and Evolution·Ziheng Yang, Rasmus Nielsen
May 29, 2002·Molecular Biology and Evolution·Maria AnisimovaZiheng Yang
Oct 5, 2002·Science·Robert A HoltStephen L Hoffman
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Aug 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·N J BesanskyN'F Sagnon
Jun 18, 2004·Immunological Reviews·George K ChristophidesFotis C Kafatos
Sep 21, 2004·Bioinformatics·D P MartinD Posada
Oct 29, 2004·Bioinformatics·Sergei L Kosakovsky PondSpencer V Muse
Feb 4, 2005·Molecular Biology and Evolution·Ziheng YangRasmus Nielsen
Feb 11, 2005·Molecular Biology and Evolution·Sergei L Kosakovsky Pond, Simon D W Frost
Feb 17, 2005·Bioinformatics·Sergei L Kosakovsky Pond, Simon D W Frost
Aug 19, 2005·Molecular Biology and Evolution·Sergei Kosakovsky Pond, Spencer V Muse
Sep 29, 2005·The Journal of Biological Chemistry·Jennifer VolzHans-Michael Müller
Jun 23, 2006·PLoS Pathogens·Yuemei DongGeorge Dimopoulos
Jul 5, 2006·Molecular Biology and Evolution·Sergei L Kosakovsky PondSimon D W Frost
Aug 10, 2006·Bioinformatics·Konrad SchefflerCathal Seoighe
Sep 30, 2006·Current Opinion in Genetics & Development·Gil McVean, Chris C A Spencer
Nov 14, 2006·EMBO Reports·Anna CohuetFotis C Kafatos
Dec 13, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Frédéric SimardTovi Lehmann
May 8, 2007·Molecular Biology and Evolution·Ziheng Yang
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anastasios C KoutsosGeorge K Christophides
Jun 26, 2007·Science·Robert M WaterhouseGeorge K Christophides
Mar 8, 2008·BMC Evolutionary Biology·Aristeidis ParmakelisJeffrey R Powell
Oct 9, 2008·BMC Evolutionary Biology·Darren J ObbardTom J Little
Feb 24, 2009·PloS One·Tovi LehmannJose' M C Ribeiro
Feb 27, 2013·The American Journal of Tropical Medicine and Hygiene·Michael R ReddyMichel A Slotman
Jan 22, 2014·The American Journal of Tropical Medicine and Hygiene·Daniel M ChisenhallChristopher N Mores

❮ Previous
Next ❯

Citations

Jun 19, 2013·Parasites & Vectors·Guoding ZhuJetsumon Sattabongkot
Jan 19, 2019·BMC Evolutionary Biology·Sushil KumarSachinandan De

❮ Previous
Next ❯

Datasets Mentioned

BETA
GU432776
GU432999

Methods Mentioned

BETA
PCR

Software Mentioned

CodonCode Aligner
MrBayes
BLAST
HypHy
RDP
Modeltest
âcodemlâ
PAML
Ensemble
FastPCR

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.