PMID: 16629426Apr 25, 2006Paper

Anorectal dysfunction in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
E MunteisJ Roquer

Abstract

To ascertain the prevalence of anorectal dysfunction (ARD) in patients with multiple sclerosis (MS) and its relationship with MS clinical characteristics. Prospective transversal study in 193 patients with MS. All patients fulfilled a protocol that included: demographic variables, clinical characteristics of MS and the presence of ARD and urinary dysfunction (UD). One hundred and ninety-three patients: 66.8% women, an average age of 42.8 (12.1) years; 67.8% of patients had relapsing remitting MS, 21.2% a secondary progressive and 10.9% a primary progressive form. The average duration of MS was 10.7 (9.4) years and the EDSS 2.8 (2.3). ARD was present in 93 patients (48.2%), and UD in 50.2%. ARD associated to UD was present in 35.7% of cases. The univariate study revealed that patients with ARD were older (P <0.001), had greater disability (P <0.0001), longer disease duration (P <0.001) and a greater association with UD (P<0.0001). ARD was more frequent in progressive forms (P<0.0001). The logistic regression analysis showed that female sex (P = 0.015), EDSS (P = 0.002) and UD (P = 0.003) were independent factors related to ARD. ARD is a highly prevalent disorder in MS. Female sex, EDSS and UD are independent predictors of ARD de...Continue Reading

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Citations

Aug 18, 2012·ISRN Neurology·Sanober NusratKlaus Bielefeldt
Jul 28, 2015·International Journal of Molecular Sciences·Alexandra PintérTimo Siepmann
Oct 24, 2008·The New England Journal of Medicine·UNKNOWN CAMMS223 Trial InvestigatorsP K Tandon
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·E MunteisJ Roquer
Jun 15, 2013·Multiple Sclerosis International·Sanober NusratKlaus Bielefeldt
May 15, 2013·European Journal of Gastroenterology & Hepatology·Giuseppe PreziosiAnton Emmanuel
Oct 21, 2011·Neurology Research International·Fary KhanLynne Turner-Stokes
Dec 12, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kilian FröhlichKlemens Winder
Jan 5, 2011·International Journal of Colorectal Disease·Amandine GuinetGérard Amarenco
Nov 26, 2010·Expert Review of Neurotherapeutics·Edward J Fox
Nov 13, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Rosaria SaccoChiara Zecca
May 1, 2021·Journal of Clinical Medicine·Giovanni MosielloMarc A Benninga
Jul 1, 2008·Journal of Neuroinflammation·William A SheremataAlireza Minagar
Feb 5, 2010·Journal of Neuroinflammation·Lawrence L HorstmanAlireza Minagar

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