Anorectal mucosal melanoma

Giulia MalaguarneraSaverio Latteri


Anorectal melanoma is an uncommon and aggressive mucosal melanocytic malignancy. Due to its rarity, the pre-operative diagnosis remains difficult. The first symptoms are non-specific such as anal bleeding, anal mass or pain. Although anorectal melanoma carries a poor prognosis; optimal therapeutics strategies are unclear. Surgical resection remains the mainstay of treatment. The optimal surgical procedure for primary tumours is controversial and can vary from wide local excision or endoscopic mucosal resection (EMR) to an abdomino-perineal resection. A high degree of uncertainly exists regarding the benefit of radiation therapy or chemotherapy. The treatment of advanced melanoma is evolving rapidly with better understanding of the disease biology and immunology. Considerable effort has been devoted to the identification of molecular determinants of response to target therapies and immunotherapy.


Mar 1, 1990·Archives of Surgery·Merrick I RossCharles M Balch
Jun 1, 1990·American Journal of Clinical Pathology·R E NakhlehL P Dehner
Oct 1, 1987·Radiology·W W WoodruffD R Voorhees
Feb 1, 1995·Diseases of the Colon and Rectum·M S BradyS H Quan
Oct 1, 1994·American Journal of Clinical Oncology·Antonio C BuzaidS Hotchkiss
Jul 1, 1993·International Journal of Colorectal Disease·P M AntoniukVictor W Fazio
Jan 1, 1993·Gastroenterology·M A Weinstock
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John M KirkwoodR H Blum
Nov 1, 1996·Annals of Surgical Oncology·G MiliotesD Reintgen
Jun 1, 1997·Seminars in Cutaneous Medicine and Surgery·M J Adler, C R White
Dec 19, 1998·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A K BosserhoffR Hein
Nov 26, 1999·Journal of the American Academy of Dermatology·D L SachsT M Johnson
Dec 22, 1999·The American Journal of Gastroenterology·D BleckerM L Kochman
Apr 25, 2000·Journal of the American Academy of Dermatology·S E Koch, J R Lange
Apr 27, 2000·Virchows Archiv : an International Journal of Pathology·C FengerJ Hilden
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·M S Marks, M C Seabra
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·G GhanemEORTC Melanoma Group
Feb 22, 2003·Journal of the American College of Surgeons·Kelli M BullardMichael P Spencer
Dec 4, 2003·British Journal of Cancer·G H WeyandtJ C Becker
Dec 18, 2003·Journal of the National Cancer Institute·Janet L MaldonadoBoris C Bastian
Apr 3, 2004·Journal of Medical Genetics·R H EdwardsB L Weber
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoram CohenWilliam H Westra
Jun 25, 2004·The British Journal of Dermatology·M A PizzichettaH P Soyer
Sep 28, 2004·The British Journal of Surgery·P PessauxP Lasser
Oct 7, 2004·Nature Immunology·Ciriana OrabonaPaolo Puccetti
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Malin SundRaghu Kalluri
Apr 22, 2005·Journal of Surgical Oncology·Léonie H M SmitBin B R Kroon
Apr 23, 2005·British Journal of Cancer·S UgurelDirk Schadendorf
May 27, 2005·Journal of Clinical Pathology·C W WongCancer Genome Project
Sep 7, 2005·Journal of Gastroenterology·Hiroyoshi MatsuokaTadahiko Masaki
Nov 18, 2005·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·William H Tolleson
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julia S JohansenPaul A Price
Nov 4, 2006·Journal of Proteome Research·An ChiDonald F Hunt
Nov 24, 2006·Annals of Surgery·Jen Jen YehMartin R Weiser
Feb 23, 2007·Nature·Vanessa Gray-SchopferRichard Marais
Mar 10, 2007·The Tohoku Journal of Experimental Medicine·K TakedaS Shibahara
Oct 20, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A HillenbrandA Formentini
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Stephen HodiDavid E Fisher
May 31, 2008·Pigment Cell & Melanoma Research·Jose LutzkyBoris C Bastian
Jul 8, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F BelliE Leo
Aug 30, 2008·British Journal of Cancer·Kevin B KimV G Prieto
Oct 22, 2008·Nature Clinical Practice. Oncology·Alfonso Quintás-CardamaPatrick Hwu
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carol BeadlingChristopher L Corless
Nov 20, 2008·British Journal of Cancer·Imke SatzgerRalf Gutzmer
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P HerseyDirk Schadendorf
Jul 22, 2009·Pigment Cell & Melanoma Research·Keith T Flaherty, Keiran S M Smalley
Jul 29, 2009·Annals of Surgical Oncology·S KruijffH J Hoekstra
Aug 8, 2009·Experimental Dermatology·P M PlonkaK U Schallreuter
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Dec 10, 2009·Dermatology : International Journal for Clinical and Investigative Dermatology·Imke SatzgerRalf Gutzmer
May 1, 2006·Clinics in Colon and Rectal Surgery·Marc Singer, Matthew G Mutch
Jan 13, 2010·Langenbeck's Archives of Surgery·Radzislaw TrzcinskiAdam Dziki
Jan 27, 2010·World Journal of Gastroenterology : WJG·Francesco BarbagalloGaetano La Greca
Feb 5, 2010·Journal of Cancer Research and Clinical Oncology·Sen ZhangDesen Wan
Mar 23, 2010·Diseases of the Colon and Rectum·Ravi P KiranVictor W Fazio
May 4, 2010·Clinics in Colon and Rectal Surgery·David Row, Martin R Weiser
Jun 3, 2010·Frontiers in Bioscience (Elite Edition)·Rosario PerrottaMariano Malaguarnera
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Feb 1, 2011·Seminars in Cutaneous Medicine and Surgery·Jose Lutzky
Apr 8, 2011·Diseases of the Colon and Rectum·Ari-Nareg MeguerditchianKelli Bullard Dunn
Apr 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Harriet M KlugerRuth Halaban
May 5, 2011·Melanoma Research·Haim GavrielMichael Henderson
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanBRIM-3 Study Group
Jan 21, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David MinorBoris C Bastian
Apr 6, 2012·Nature Reviews. Cancer·Keith T FlahertyDavid E Fisher
Sep 5, 2012·Oncogene·Ryan J Sullivan, Keith T Flaherty
Nov 7, 2012·Molecular and Cellular Biochemistry·Michelino Di RosaLucia Malaguarnera
Nov 15, 2012·Inflammation·Michelino Di RosaLucia Malaguarnera
Nov 16, 2012·Cell Biochemistry and Biophysics·Michelino Di RosaLucia Malaguarnera
May 15, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chuanliang CuiJun Guo
May 17, 2013·American Journal of Clinical Dermatology·Marta BatusHoward L Kaufman
Aug 7, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo A AsciertoUwe Trefzer
Sep 18, 2013·European Journal of Radiology·Nicole WinklerAkram Shaaban
Sep 24, 2013·Lancet·Alexander M M EggermontCaroline Robert
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ryan J SullivanKeith T Flaherty
Oct 9, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michele Del VecchioMichele Maio
Mar 19, 2014·Frontiers in Physiology·Vladimir RiabovJulia Kzhyshkowska
Mar 26, 2014·Head & Face Medicine·Liviu FellerJohan Lemmer
Nov 16, 2014·Journal of Clinical Pathology·Raffaella SantiDaniela Massi
Dec 4, 2014·World Journal of Gastroenterology : WJG·Giulia MalaguarneraMichele Malaguarnera
Jan 31, 2015·World Journal of Surgical Oncology·Dominique BuissinPeter C Ambe
Apr 7, 2015·Chinese Clinical Oncology·Xuan WangJun Guo
Mar 24, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lauge H MikkelsenSteffen Heegaard
Apr 15, 2016·Melanoma Research·Merete KroghNordic Melanoma Group and EORTC Melanoma Group
Apr 30, 2016·Nature Reviews. Cancer·A Hunter Shain, Boris C Bastian
Aug 16, 2016·Environmental Science and Pollution Research International·Yolande AsaraRoberto Madeddu
Nov 9, 2016·Aging Clinical and Experimental Research·Giulia MalaguarneraSaverio Latteri
Feb 9, 2017·European Journal of Dermatology : EJD·Julia ThieraufThomas K Hoffmann
Mar 25, 2017·Journal of Medical Case Reports·Vito Emanuele CataniaSaverio Latteri
Apr 17, 2017·Oncotarget·Sheng WangShupeng Wang
Jun 9, 2017·Journal of Ultrasound·Saverio LatteriMario Scuderi
Jun 15, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Gaetano La GrecaSaverio Latteri
Sep 22, 2017·Journal of Thoracic Disease·Giulia MalaguarneraMichele Malaguarnera


Feb 24, 2018·Biomedicines·Saverio LatteriMichele Malaguarnera
Mar 5, 2019·World Journal of Surgery·James P TaylorJonathan E Efron
Jun 25, 2019·International Journal of Surgical Pathology·Phoenix D BellXiaoyan Liao
Jul 28, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·So-Woon KimIn Ja Park
Aug 28, 2020·Journal of Community Hospital Internal Medicine Perspectives·Ho-Man YeungBhishak Kamat

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