Anorectic effect of lisuride and other ergot derivatives in the rat

European Journal of Pharmacology
M O CarrubaP Mantegazza

Abstract

Three ergot derivatives, lisuride, lergotrile and bromocriptine, given to rats trained to eat 4 h a day, induced a dose- and time-related anorexia. They were more potent in this context than either amphetamine or fenfluramine. Lisuride and lergotrile failed to increase locomotor activity or to induce stereotyped behaviour at doses corresponding to the ID50 on food intake. At this dose, bromocriptine slightly stimulated motor activity. The anorectic effect of the three compounds was selectively antagonized by blockers of dopamine (DA) receptors in the central nervous system but not by either inhibiton of catecholamine synthesis or blockade of alpha- or beta-adrenoceptors or of serotonergic receptors. Also two blockers of 'peripheral' DA receptors failed to antagonize ergoline-induced anorexia. These findings indicate that stimulation of DA receptors involved in feeding behaviour was responsible for the anorexigenic effect of the ergot derivatives investigated. In most instances this effect occurred at dose levels which failed to induce central stimulant effects.

References

Jan 1, 1977·The Journal of Pharmacy and Pharmacology·R SamaninS Garattini
May 1, 1979·Neuropharmacology·S L Burridge, J E Blundell
Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A LiuzziR Horowski
Dec 1, 1977·Life Sciences·E E MůllerP Mantegazza
Jan 1, 1979·Psychiatria Clinica·D De MaioG Scieghi
May 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M O CarrubaP Mantegazza
Apr 1, 1976·European Journal of Pharmacology·F ZambottiP Mantegazza
Jan 1, 1973·The Journal of Pharmacy and Pharmacology·S Jespersen, J Scheel-Krüger
Nov 1, 1973·The Journal of Pharmacy and Pharmacology·F BarzaghiE E Müller
Jun 1, 1971·The Journal of Pharmacy and Pharmacology·W H FunderburkJ W Ward
Nov 23, 1974·British Medical Journal·D B CalneA Petrie
Nov 14, 1973·Nature: New Biology·Z L Kruk
Dec 1, 1977·Neuroscience Letters·M Da PradaH H Keller

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Citations

Aug 4, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·P RiedererP Kruzik
Apr 4, 1995·European Journal of Pharmacology·V L GarosiM O Carruba
Dec 1, 1982·Neuropharmacology·S P ArnerićJ P Long
Nov 1, 1994·Physiology & Behavior·F Ferrari, D Giuliani
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·J T ClarkJ M Davidson
Aug 1, 1985·Pharmacology, Biochemistry, and Behavior·S B GreeneC P Garbin
May 1, 1989·Pharmacology, Biochemistry, and Behavior·P G CliftonS J Cooper
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·F FerrariD Giuliani
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·L Pulvirenti, G F Koob
May 1, 1994·Pharmacology, Biochemistry, and Behavior·G A van der Hoek, S J Cooper
Jan 1, 1987·Pharmacology & Therapeutics·J E Blundell, P L Thurlby
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
Jan 1, 1991·General Pharmacology·M R ZarrindastT Hosseini-Nia
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·K InoueS Yamagami
Apr 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·F KayaA S Van Miert
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany
Jul 25, 2007·Clinical Endocrinology·Erika C O NaliatoAnnamaria Colao
Apr 1, 1988·Acta Neurologica Scandinavica·P GiovanniniT Caraceni
Nov 1, 1995·Obesity Research·P TerryS J Cooper
Dec 3, 1984·Klinische Wochenschrift·G OllenschlägerJ Schindler

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