PMID: 11333095May 3, 2001Paper

Anorexia and the effect of internal biliary drainage on food intake in patients with obstructive jaundice

Journal of the American College of Surgeons
F J PadilloA Sitges-Serra

Abstract

Anorexia is a frequent finding in patients with biliary obstruction (BO). This study investigates the role of biochemical and hormonal factors in the pathogenesis of reduced food intake in BO and the effects of internal biliary drainage. Sixty-two patients with BO were prospectively investigated. Transaminases, amylase, cholecystokinin, secretin, bile acids, tumor necrosis factor-alpha, and endotoxin were determined at admission. Caloric intake was quantified by a controlled diet. In a subset of 27 patients, studies were repeated after internal biliary drainage. Sixty-six percent of patients had spontaneous food intakes below the estimated caloric requirements. Serum bilirubin, alkaline phosphatase, and cholecystokinin plasma levels were independent predictor factors for calorie intake (p = 0.0001). After internal biliary drainage, cholestasis parameters and cholecystokinin concentrations decreased significantly; this was associated with an improvement of spontaneous food intake in both benign and malignant biliary obstruction (p < 0.01 and p < 0.05, respectively). Decreased food intake in BO was associated with the degree of obstruction and with increased cholecystokinin plasma levels. Biliary drainage improved biochemical and...Continue Reading

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Citations

Feb 3, 2009·Journal of Hepato-biliary-pancreatic Surgery·Yasuhiro FujinoYoshikazu Kuroda
Mar 15, 2005·Life Sciences·Mohammad R EbrahimkhaniAhmad R Dehpour
Nov 15, 2002·Nutrition·F J PadilloA Sitges-Serra
Aug 30, 2008·Techniques in Vascular and Interventional Radiology·Anne M Covey, Karen T Brown
Apr 13, 2019·Journal of Surgical Oncology·Ahsun RiazRobert J Lewandowski
Oct 24, 2014·World Journal of Gastroenterology : WJG·José M AlamoFrancisco J Padillo
Sep 22, 2017·International Journal of Molecular Sciences·Stefan Heinrich, Hauke Lang
May 1, 2021·Cancers·Sarah Powell-BrettKeith J Roberts
May 27, 2021·Expert Review of Gastroenterology & Hepatology·Sarah BlackerAdam E Frampton

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