Anorexia during febrile conditions in dwarf goats. The effect of diazepam, flurbiprofen and naloxone

The Veterinary Quarterly
A S van MiertS M Anika

Abstract

The most common sign of febrile diseases is anorexia, which develops at a time when adequate caloric and micronutrient availability may be critical. In order to study the relationship of fever and anorexia, feed intake in dwarf goats was studied under conditions of fever and antipyresis. Furthermore, experiments were done to establish whether a feed intake stimulant would override the anorexia during febrile conditions. Infection with Ehrlichia phagocytophila and i.v. injection of Escherichia coli endotoxin (0(111) B4, 0.1 microgram/kg body weight) both resulted in increased rectal temperatures and significant reductions in feed intake. Administration of the antipyretic drug flurbiprofen (1 mg/kg) to febrile animals inhibited the temperature responses, but food intake was still suppressed. Diazepam (0.06 mg/kg), a feed intake stimulant, did not override the anorexia associated with fever. Blocking the febrile response of E. coli LPS-injected goats with flurbiprofen plus diazepam or with flurbiprofen plus naloxone (0.1 mg/kg) did not antagonise their reduced feed intake either. The effects of these drugs and of endotoxin on rumen motility adds an interesting aspect to their activities in the CNS, since the CNS has been shown to ...Continue Reading

References

Aug 1, 1977·European Journal of Pharmacology·A S Van Miert, C T Van Duin
May 1, 1985·Archives internationales de physiologie et de biochimie·K Venkatarami Reddy, S Govindappa
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S J Cooper, L B Estall
Sep 1, 1985·Veterinary Research Communications·S M Anika
Mar 12, 1966·Nature·D ThienpontP A Janssen
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Aug 1, 1984·The American Journal of Clinical Nutrition·D O McCarthyA J Vander
Aug 19, 1983·European Journal of Pharmacology·A S Van MiertF M Woutersen-Van Nijnanten
Aug 1, 1981·Physiology & Behavior·C A BaileC A Catanzaro
Jan 8, 1982·European Journal of Pharmacology·C L Maas
Feb 1, 1981·Thorax·C W Edwards, H R Matthews
Jun 1, 1981·Physiology & Behavior·C A BaileC L McLaughlin

❮ Previous
Next ❯

Citations

Sep 1, 1989·Physiology & Behavior·W LanghansE Scharrer
Jan 1, 1987·Veterinary Research Communications·A S Van Miert
Dec 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·A S van MiertT Wensing
Mar 21, 1998·Journal of Veterinary Pharmacology and Therapeutics·A S van Miert, C T van Duin
Oct 6, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roger M NisbetLeah R Johnson
Feb 1, 1994·Biological Reviews of the Cambridge Philosophical Society·W Wieser
Aug 1, 1994·Infection and Immunity·K J Biberstine, R S Rosenthal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.