Anorexia nervosa, emotional go/no-go, and the distinct effect of testosterone

The International Journal of Eating Disorders
Tom HildebrandtKurt Schulz

Abstract

Behavioral disinhibition in the context of negative emotion (e.g., disgust, fear, etc.) may promote the core psychopathology of anorexia nervosa (AN). Affective models of AN position a number of clinical behaviors as functioning to reduce negative affect. Gonadal hormone dysregulation, in particular testosterone, likely plays some role in this process. Adolescent and young adult AN (n = 32) and healthy control (HC; n = 20) participants completed an emotional go/no-go task-a valenced measure of behavioral disinhibition-and had blood drawn to assess gonadal steroid hormone concentrations. Analyses indicated that patients with AN committed significantly more commission errors, which measures the tendency to respond to nontarget stimuli. This effect was qualified by the valence of the stimulus; the higher relative level of error was true for disgust and happy stimuli, but not neutral stimuli. Hormone analyses revealed a testosterone by group interaction. Testosterone was associated with decreased commission errors for patients with AN, but had no discernible relationship with task outcome for HCs. These effects were not confounded by weight, pubertal status, or self-reported anxiety or depression. These findings suggest patients wi...Continue Reading

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May 26, 2016·Current Psychiatry Reports·Kristen M CulbertKelly L Klump
Dec 1, 2020·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Amy HarrisonKate Tchanturia
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Nov 17, 2020·Journal of Psychiatric Research·Tyler B MasonKathryn E Smith

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Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

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