Anosognosia and anosodiaphoria in mild cognitive impairment and Alzheimer's disease

Dementia and Geriatric Cognitive Disorders Extra
Maria Lindau, Randall Bjork

Abstract

To evaluate the occurrence of anosognosia (lack of awareness) and anosodiaphoria (insouciance) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and to evaluate the influence of a worsening of dementia on these phenomena. A self-evaluation scale was used assessing degrees of anosognosia and anosodiaphoria; furthermore, a neuropsychological assessment and statistical analyses with nonparametric tests which could cope with data on an ordinal scale level and small samples were employed. Cognitive ability was lower in AD (n = 9) than in MCI patients (n = 12), but AD patients self-rated lower cognitive disabilities, which is interpreted as one relative sign of anosognosia in AD. Awareness of the reasons for cognitive problems was also lower in AD, which is considered as another sign of anosognosia. The main pattern in MCI found that the higher the awareness, the lower the cognitive ability. In AD low awareness paralleled low cognitive functioning. Anosodiaphoria was present in AD but not in MCI. According to the literature anosognosia and anosodiaphoria seem to increase with progression of dementia from MCI as a result of right hemispheric alterations.

Citations

May 17, 2018·International Journal of Geriatric Psychiatry·Alexandre de MendonçaManuela Guerreiro
Apr 14, 2020·Journal of the American Geriatrics Society·Pei-Jung LinKaren M Freund
Dec 9, 2015·International Journal of Geriatric Psychiatry·Mary KelleherJames E Galvin
Aug 28, 2020·BMJ Case Reports·Sarah Louise GillandersMartin Jude Donnelly
Dec 18, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lulu LiuMuireann Irish

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