Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches

PloS One
Rajesh DurairajCécile Bienboire-Frosini

Abstract

The mammalian secretoglobin (SCGB) superfamily contains functionally diverse members, among which the major cat allergen Fel d 1 and mouse salivary androgen-binding protein (ABP) display similar subunits. We searched for molecular similarities between Fel d 1 and ABP to examine the possibility that they play similar roles. We aimed to i) cluster the evolutionary relationships of the SCGB superfamily; ii) identify divergence patterns, structural overlap, and protein-protein docking between Fel d 1 and ABP dimers; and iii) explore the residual interaction between ABP dimers and steroid binding in chemical communication using computational approaches. We also report that the evolutionary tree of the SCGB superfamily comprises seven unique palm-like clusters, showing the evolutionary pattern and divergence time tree of Fel d 1 with 28 ABP paralogs. Three ABP subunits (A27, BG27, and BG26) share phylogenetic relationships with Fel d 1 chains. The Fel d 1 and ABP subunits show similarities in terms of sequence conservation, identical motifs and binding site clefts. Topologically equivalent positions were visualized through superimposition of ABP A27:BG27 (AB) and ABP A27:BG26 (AG) dimers on a heterodimeric Fel d 1 model. In docking, ...Continue Reading

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Citations

Feb 23, 2020·International Journal of Molecular Sciences·Cécile Bienboire-FrosiniPatrick Pageat
Jan 19, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Rodrigo Ligabue-Braun

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Methods Mentioned

BETA
protein folding

Software Mentioned

Swiss
ClustalO
Molecular Evolutionary Genetics Analysis ( MEGA )
MEGA Wizard
ClusPro
ExPASy
ViewDock
ConSurf
UCSF Chimera
MEGA

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