Abstract
Dravet syndrome has been found recently as an important underlying condition in cases of alleged vaccine encephalopathy after pertussis vaccination, where vaccination seemed to have precipitated the occurrence of the disease without modifying the long-term course. We report on a patient diagnosed with Angelman syndrome in her fifth decade, in whom the intellectual disability and epilepsy had been assumed to be caused by a vaccine encephalopathy following smallpox vaccination. Clinical features of Angelman syndrome had faded away. The history of the present patient suggests that genetic conditions other than Dravet syndrome can be associated with an alleged vaccine encephalopathy. A history of vaccine encephalopathy is rare among patients with learning disability and refractory epilepsy (1.4% in our cohort), but it should lead to consideration of a comprehensive genetic work-up if Dravet syndrome is excluded. The early history of the patient, when available, should guide the investigations. Medico-legal aspects are also discussed.
References
Feb 1, 1997·Epilepsia·L A LaanO F Brouwer
Feb 5, 2003·Journal of Medical Genetics·J Clayton-Smith, L Laan
Apr 23, 2003·Neurology·John Booss, Larry E Davis
May 23, 2006·Lancet Neurology·Samuel F BerkovicIngrid E Scheffer
Aug 22, 2006·Nature Neuroscience·Frank H YuWilliam A Catterall
Nov 16, 2006·Epilepsia·Markus WolffCharlotte Dravet
Oct 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Raffaella RusconiMassimo Mantegazza
May 21, 2009·Epilepsia·Ronald L ThibertElizabeth A Thiele
Mar 2, 2010·Developmental Medicine and Child Neurology·Brian Neville
May 7, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Charles A WilliamsAditi I Dagli
May 8, 2010·Lancet Neurology·Anne M McIntoshSamuel F Berkovic
Mar 3, 2011·European Journal of Human Genetics : EJHG·Fadi F HamdanJacques L Michaud
Apr 8, 2011·Epilepsia·Carla MariniRenzo Guerrini
Apr 8, 2011·Epilepsia·Catherine Chiron, Olivier Dulac
Jun 23, 2011·Epilepsia·Akihisa OkumuraToshiaki Shimizu
Jun 28, 2011·Cell·Tara KlassenJeffrey Noebels
Aug 17, 2011·Pediatrics·Ila S ReyesAngus A Wilfong
Nov 19, 2011·Epilepsia·Akihisa OkumuraToshiaki Shimizu
Citations
Dec 6, 2012·European Journal of Human Genetics : EJHG·Inge HeulensPeter Hammond
Oct 16, 2012·Gene·Antonietta CoppolaSanjay M Sisodiya
Aug 7, 2013·American Journal of Medical Genetics. Part a·Mauren Abreu de SouzaPeter Hammond
Jun 15, 2019·CNS Neuroscience & Therapeutics·Xinchen TengJ Marie Hardwick