Another link between phospholipid transmembrane migration and ABC transporter gene family, inferred from a rare inherited disorder of phosphatidylserine externalization

Biochemical and Biophysical Research Communications
F TotiJ-M Freyssinet

Abstract

The mechanisms involved in the maintenance or loss of the asymmetric distribution of phospholipids in the cell plasma membrane remain mysterious. In the yeast Saccharomyces cerevisiae, the transmembrane migration of certain phospholipids is controlled by transcription regulators of various ATP-binding cassette (ABC) transporters. The P-glycoprotein membrane transporters encoded by the multidrug resistance (MDR) genes, members of the ABC protein family, act as lipid translocases in mammalian cells. We report here the lack of expression of MDR genes in lymphoblasts derived from the B cells of a patient with an inherited Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications. From microsatellite analysis of 7q21.1 and functional assessment, the most likely explanation accounting for Scott phenotype is a mutation in an unlinked gene coding for a regulatory protein necessary for the expression of MDR genes. Because phosphatidylserine externalization is also one of the hallmarks of cells undergoing apoptosis, these observations are suggestive of a relationship between basic processes such as multidrug transport, apoptosis and procoagulant phospholipid exposure.

Citations

Jun 19, 2012·Annual Review of Microbiology·Rajendra Prasad, Andre Goffeau
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Shigeki SugawaraKazuo Nitta
Oct 10, 2001·Current Biology : CB·P M HensonV A Fadok
Jul 11, 2006·Microbes and Infection·Nicolas ColtelGeorges E Grau
Apr 3, 2004·Trends in Molecular Medicine·Beatrice Cambien, Denisa D Wagner
Nov 20, 1998·FEBS Letters·M LigrD H Wolf
Sep 27, 2015·Eukaryotic Cell·Rajendra PrasadSanjiveeni Dhamgaye
Dec 17, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Olivier MorelFlorence Toti
Aug 21, 2010·Der Internist·C M Kirchmaier, D Pillitteri
Jul 10, 2001·American Journal of Physiology. Cell Physiology·K Lange, J Gartzke
Aug 14, 1999·Biochimica Et Biophysica Acta·E M BeversR F Zwaal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.