PMID: 2496430Jan 1, 1989Paper

Another look at amphetamine-induced stereotyped locomotor activity in rats using a new statistic to measure locomotor stereotypy

Psychopharmacology
K MuellerD R Cross

Abstract

Rat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animal's path through the open field is converted into a series of trips. Gamma (gamma) estimates the probability that the animal will repeat the trip that it has just exhibited; thus gamma quantifies "locomotor stereotypy". Trip lengths can also be compared across drug groups. Thus caffeine has no effect on gamma even though it produces a dose-related increase in locomotions. Caffeine does not produce amphetamine-like stereotypy. On the other hand, amphetamine produces a dose-related increase in gamma. Although gamma was designed to detect any pattern of locomotor behavior, rats treated with high doses of amphetamine almost always exhibited the same pattern of locomotor behavior - repetitive trips around the perimeter of the open field. Although further characterization of the statistic is necessary, these findings suggest that gamma has potential for quantifying "locomotor stereotypy" and for providing a more subtle description of locomotor behavior in general.

References

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Citations

Jan 1, 1989·Psychopharmacology·K MuellerC Haskett
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·K Mueller, J L Peel
Jan 1, 1990·Behavioural Brain Research·D Eilam, I Golani
Sep 1, 1993·Neurotoxicology and Teratology·P M KunkoS E Robinson
Dec 1, 1996·Pharmacology, Biochemistry, and Behavior·P M KunkoS E Robinson
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·M E FrittsL Morris
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·M E FrittsL Morris
Feb 1, 2005·Pharmacology, Biochemistry, and Behavior·Neri Kafkafi, Gregory I Elmer
Oct 29, 2005·Neuroscience and Biobehavioral Reviews·David EilamHaggai Hermesh
Sep 21, 2013·Journal of Psychopharmacology·Fausto A VarelaSanders A McDougall
Feb 11, 2000·Toxicologic Pathology·J F Ross Ross

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