Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Andrew A Wilson, Darrell N Kotton

Abstract

Previous work has suggested that many stem cells can be found in microanatomic niches, where adjacent somatic cells of the niche control the differentiation and proliferation states of their resident stem cells. Recently published work examining intestinal stem cells (ISCs) in the adult Drosophila midgut suggests a new paradigm where some stem cells actively control the cell fate decisions of their daughters. Here, we review recent literature((1)) demonstrating that, in the absence of a detectable stem cell niche, multipotent Drosophila ISCs modulate the Notch signaling pathway in their adjacent daughter cells in order to specify the differentiated lineages of their descendants. These observations made in Drosophila are challenging and advancing our understanding of stem cell biology.

References

Jan 1, 1995·Annual Review of Cell and Developmental Biology·S J MorrisonI L Weissman
Mar 24, 2004·Cell·Elaine FuchsGeraldine Guasch
Jun 16, 2004·Current Opinion in Cell Biology·Fabrice Roegiers, Yuh Nung Jan
Nov 9, 2004·Current Opinion in Cell Biology·Benjamin OhlsteinAllan Spradling
Jun 1, 2005·Experimental Cell Research·Daniel Pinto, Hans Clevers
Oct 4, 2005·Developmental Cell·Eva Decotto, Allan C Spradling
Dec 13, 2005·Nature·Craig A Micchelli, Norbert Perrimon
Dec 13, 2005·Nature·Benjamin Ohlstein, Allan Spradling
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
Nov 3, 2006·Genes & Development·Cédric BlanpainElaine Fuchs
Mar 27, 2007·Cell·Maria Xenia G Ilagan, Raphael Kopan

❮ Previous
Next ❯

Citations

Jan 10, 2008·Annual Review of Cell and Developmental Biology·Shahragim TajbakhshIsabelle Le Roux
Nov 17, 2009·Journal of Insect Physiology·James B NardiLou Ann Miller
Oct 6, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Craig A Micchelli
Apr 30, 2015·Trends in Genetics : TIG·Terry L Orr-Weaver
Jan 9, 2009·Cell Stem Cell·Alla AmcheslavskyY Tony Ip
Feb 1, 2011·Journal of Insect Physiology·James B NardiBenjamin Ohlstein
Jun 21, 2016·Developmental Biology·Shigeo TakashimaVolker Hartenstein
Sep 20, 2017·Cell Communication and Signaling : CCS·Qiang Liu, Li Hua Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.