Another potential source of error in Rh-hr typing

Transfusion
M E ReidB A Frank

Abstract

Three cases are presented in which the presence of sodium caprylate dependent albumin auto-agglutinins in the patients' sera resulted in erroneous Rh-hr phenotyping of their erythrocytes. In the initial testing, the albumin control was negative in each case. Since one of the cases was an Rh0(D) negative individual whose red blood cells might have been classified as Rh0(D) positive, a study was made using routine Rh-hr typing reagents from different manufacturers. Attention is drawn to the fact that Rh-hr typings should be performed using washed red blood cell samples when serum is known to contain albumin autoagglutinins.

Related Concepts

Isoantibodies
Antigen D, Rh Blood Group
Serotyping
Plasma Albumin

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