PMID: 785019Aug 1, 1976

Antacid control of complications from acute gastroduodenal disease after burns

The Journal of Trauma
J C McAlhanyBasil A Pruitt


To determine the effectiveness of hydrogen ion neutralization in preventing the clinical complications (hemmorrhage and perforation) of acute gastroduodenal disease after thermal injury, 48 patients with burns of greater than 35% total body surface were evaluated within 72 hours after injury. In a prospective, randomized fashion, patients were chosen to receive antacid or no-antacid therapy. An established lithiumflux technique was utilized to determine the integrity of the gastric mucosal barrier (GMB) before group selection. Only one of the 24 patients receiving antacid developed significant upper gastrointestinal bleeding; however, seven of 24 patients receiving no antacid experienced hemorrhage and gastric ulcer perforation (p less than 0.02). None of seven patients with GMB disruption who received antacid developed a clinical complication; however, six of 15 patients with GMB disruption receiving no antacid experienced clinical complications (p less than 0.05). Neutralization of gastric acid offers protection against the development of clinically significant ulcer complications in the burn patient.


Mar 1, 1981·World Journal of Surgery·C E Lucas
Mar 1, 1981·World Journal of Surgery·Basil A Pruitt, C W Goodwin
Mar 1, 1981·World Journal of Surgery·H J Priebe, J J Skillman
Jan 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D E Craven, F D Daschner
Jun 1, 1997·Burns : Journal of the International Society for Burn Injuries·T RaffB Hartmann
Jun 3, 2000·Gastroenterology Clinics of North America·U Beejay, M M Wolfe
May 24, 2003·Best Practice & Research. Clinical Gastroenterology·Donald R Duerksen
Sep 1, 1994·Annals of Surgery·R V MaierL Gentilello
Feb 6, 1999·Critical Care Medicine·N P LamS Patel
Jun 15, 2006·Annals of Surgery·Basil A Pruitt
Mar 4, 1978·British Medical Journal
Jun 1, 1979·Gut·T Morris, J Rhodes
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·B L ErstadS J Martin
Aug 3, 2014·The Surgical Clinics of North America·Basil A Pruitt
Mar 1, 1979·Intensive Care Medicine·J R Croker
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·A Berstad
Aug 1, 1991·Scandinavian Journal of Gastroenterology·R EstruchA Urbano-Márquez
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·D J Cook
Oct 2, 2009·Clinics in Plastic Surgery·Basil A Pruitt, Steven E Wolf
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S Bengmark
Apr 1, 1982·The Journal of Surgical Research·S CliftD L Kaminski
Jul 1, 1991·Current Problems in Surgery·T A MillerF G Moody
Jun 1, 1987·Burns, Including Thermal Injury·J K PrasadI Feller
Dec 1, 1988·American Journal of Surgery·J S CounceF T Caldwell
Jun 3, 2000·Gastroenterology Clinics of North America·Y KupferS Tessler
Jul 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·M M GottschlichJ W Alexander
Jun 5, 2018·The Cochrane Database of Systematic Reviews·Ingrid ToewsJoerg J Meerpohl
Jan 1, 1991·Annals of the New York Academy of Sciences·J G Moore
Mar 26, 2019·Acta Anaesthesiologica Scandinavica·Martine Marker JensenM H Møller
Feb 6, 2016·Current Opinion in Critical Care·M KragMorten Hylander Møller
Aug 1, 1985·Anaesthesia and Intensive Care·K Hillman
Mar 1, 1983·The Japanese Journal of Surgery·A E Baue, D Guthrie
Apr 1, 1993·Alimentary Pharmacology & Therapeutics·L Laine
Feb 1, 1996·Critical Care Medicine·T Ben-MenachemR S Bresalier
Sep 25, 1998·Medizinische Klinik·S KressJ F Riemann
Sep 1, 1994·The Annals of Pharmacotherapy·M A Smythe, B J Zarowitz
Jan 1, 1991·Alimentary Pharmacology & Therapeutics·J G Moore
Mar 27, 2018·Acta Anaesthesiologica Scandinavica·M BarbateskovicM H Møller

Related Concepts

Acute Disease
Burn Injury
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Duodenal Ulcer
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Peptic Ulcer Hemorrhage
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