Antacid therapy for gastroesophageal reflux in preterm infants: a systematic review

BMJ Paediatrics Open
Elda DermyshiJon Dorling

Abstract

Gastro-oesophageal reflux is prevalent in preterm infants. Despite widespread use in clinical practice, there is still much controversy over the efficacy and safety of drug interventions, particularly antacid therapy. To systematically review the effects of antacid therapy on preterm infants with symptoms of gastro-oesophageal reflux, and to assess the safety of these interventions. We carried out an electronic search of the Cochrane central register of controlled trials (CENTRAL, The Cochrane Library), MEDLINE (1966-present), EMBASE (1980-present) and CINAHL (1982-present) as well as other online sources. Participants were preterm infants (<37 weeks gestation) with gastro-oesophageal reflux disease who were receiving care on a neonatal unit. We assessed the effects of histamine-2 receptor antagonists, proton pump inhibitors and alginates against placebo, primarily to see if they reduced the symptoms of reflux. Six studies were included in this review. Meta-analysis could not be carried out due to a lack of studies assessing the same intervention with the same outcomes. Omeprazole therapy significantly reduced the oesophageal acid exposure percentage time with pH<4 (p<0.01) and sodium alginate significantly decreased gastro-oes...Continue Reading

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Citations

Feb 7, 2020·Acta Paediatrica·Elvira I LevyYvan Vandenplas
Jul 2, 2020·Pediatric Quality & Safety·Richelle M ReinhartMary L Nock
Feb 12, 2019·Expert Review of Clinical Pharmacology·Karel AllegaertJohn Van Den Anker
Oct 31, 2021·Pediatric Research·Haslina Binti Abdul HamidShalini Ojha

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