PMID: 38192Jun 1, 1979

Antacids and peptic ulcer--a reappraisal

Gut
T Morris, J Rhodes

Abstract

Antacids can reduce gastroduodenal acidity for long periods if taken in substantial quantities after food. Their healing effect on gastric ulcer is minimal, if present at all, and easily overwhelmed by the benefit obtained from admission to hospital. Intensive antacid therapy appears effective in healing duodenal ulcer and preventing haemorrhage from stress ulcer, and is comparable in these respects with cimetidine but with a higher incidence of side-effects. Clinical impression strongly suggests that antacids relieve pain in peptic ulcer but objective confirmation is lacking.

References

Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·V S Westerberg, J D Geiger
Nov 1, 1984·Gut·R C Heading
Sep 1, 1984·Postgraduate Medical Journal·M R JacynaK G Wormsley
Jan 1, 1981·Scandinavian Journal of Gastroenterology·M StrömA Walan
Nov 1, 1984·Journal of Pharmaceutical Sciences·R J SepelyakS L Hem
Dec 1, 1980·Australian and New Zealand Journal of Medicine·W P Fung
Jul 15, 2015·Drug Metabolism and Personalized Therapy·Shabnam DelasoudHamidreza Mollasalehi

Citations

Jan 1, 1978·British Journal of Diseases of the Chest·J Webb
Feb 18, 1978·British Medical Journal·R E Barry, J Ford
Jul 24, 1976·Lancet·W S BlackwoodT C Northfield
Aug 14, 1975·The New England Journal of Medicine·G LevyL K Garrettson
Jan 1, 1977·Scandinavian Journal of Infectious Diseases·R Steffen
Aug 1, 1976·The Journal of Trauma·J C McAlhanyB A Pruitt
Jun 16, 1977·The New England Journal of Medicine·W D KaehnyA C Alfrey
Aug 18, 1977·The New England Journal of Medicine·W L PetersonJ S Fordtran
Mar 1, 1976·Brain : a Journal of Neurology·D R CrapperS Quittkat
Sep 1, 1975·The American Journal of Digestive Diseases·M L Butler, H Gersh
Aug 11, 1975·JAMA : the Journal of the American Medical Association·J I Isenberg
Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Dec 3, 1973·JAMA : the Journal of the American Medical Association·D Hollander, J Harlan
Jan 1, 1974·Gut·K G Wormsley
Nov 1, 1974·Journal of Clinical Pharmacology·J E Bernstein, A M Kasich
Jan 1, 1972·Scandinavian Journal of Gastroenterology·S Aukee
May 3, 1973·The New England Journal of Medicine·J S FordtranC T Richardson
Sep 13, 1973·The New England Journal of Medicine·J A LevantJ I Isenberg
Mar 23, 1974·British Medical Journal·C E Dent, C S Winter
Jun 18, 1970·The New England Journal of Medicine·R F Barreras
Oct 16, 1969·The New England Journal of Medicine·W L Trudeau, J E McGuigan
Apr 28, 1966·The New England Journal of Medicine·J S Fordtran, J A Collyns
Jan 1, 1957·Gastroenterologia·R DOLLJ L STUBBE
Jan 11, 1962·The New England Journal of Medicine·J P DUNN, L E ETTER
May 1, 1964·Scottish Medical Journal·R DOLL
Oct 24, 1968·The New England Journal of Medicine·J S Fordtran

Related Concepts

Gastric Juice
Hemorrhagic Septicemia
Gastric Ulcer
Marginal Ulcer
Tagamet
Alhydrogel
Duodenal Ulcer
Antacids
Clinical Trials
Peptic Ulcer Hemorrhage

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