PMID: 38999Jul 1, 1979

Antagonism between dopaminergic and neuroleptic drugs. II. Chronic administration

Il Farmaco; edizione scientifica
A TartaraF Savoldi


In this work the eeg and behavioural effects obtained after the administration of dopaminergic drugs (bromocriptine, apomorphine, piribedil) in rabbits chronically pretreated with haloperidol, chlorpromazine, clotiapine, are shown. The Monnier and Gangloff stereotaxic method was used. The aim of the study was to verify receptor supersensitivity by neurophysiologic methods. The neurophysiologic pattern of receptor supersensitivity induced by long-lasting treatment with neuroleptic drugs and its peculiarity are discussed.

Related Concepts

Antipsychotic Effect
Vigilance, Cortical
Dopaminergic Agents
Assay OF Haloperidol
Antipsychotic Agents

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