Antagonism by benzodiazepines of the effects of serotonin-, but not norepinephrine-, uptake blockers in the learned helplessness paradigm in rats

Biological Psychiatry
P Martin, A J Puech

Abstract

Benzodiazepines are routinely administered in combination with antidepressant drugs. Such combination can induce pharmacodynamic or pharmacokinetic interactions resulting in either a potentiation or a reduction of the effects of one of the drugs. The present study was undertaken to determine the effects of benzodiazepines alone and in combination with two classes of antidepressant drugs: "specific" norepinephrine uptake blockers (desipramine, maprotiline) and specific serotonin uptake blockers (indalpine, fluvoxamine) in the learned helplessness paradigm in rats. The present results show that daily injection of diazepam (0.2-2 mg/kg) and lorazepam (0.06-0.25 mg/kg) did not reverse the helpless behavior. The reversal of helpless behavior induced by indalpine (1 mg/kg/day) or fluvoxamine (4 mg/kg/day) was antagonized dose-dependently by daily coadministration of benzodiazepines. In contrast, the effects of desipramine (24 mg/kg/day) or maprotiline (48 mg/kg/day) were not modified.

References

Jan 1, 1990·Psychopharmacology·P MartinA J Puech
Jan 1, 1990·Pharmacology & Therapeutics·P Willner
Jan 1, 1988·Journal of Pharmaceutical Sciences·M OkiyamaH Kitagawa
Apr 1, 1988·Clinical Pharmacology and Therapeutics·L LembergerR F Bergstrom
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·P MartinP Simon
May 1, 1967·Journal of Experimental Psychology·M E Seligman, S F Maier
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Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·A D ShermanF Petty

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Citations

Jan 5, 2002·European Journal of Pharmacology·F Borsini, R Cesana
Jan 30, 2007·Pharmacology, Biochemistry, and Behavior·Takayoshi MamiyaYukihiro Noda
Feb 8, 2005·Brain Research·Benjamin N GreenwoodMonika Fleshner
Jul 4, 2012·Biological Psychiatry·Clement Hamani, José N Nobrega
May 28, 2020·International Clinical Psychopharmacology·Bryant LimSakina J Rizvi
Nov 11, 2020·The European Journal of Neuroscience·Izaque de Sousa MacielSâmia R L Joca

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