PMID: 6408677Jan 1, 1983Paper

Antagonism of a behavioral effect of LSD and lisuride in the cat

Psychopharmacology
F J WhiteJ B Appel

Abstract

These experiments investigated the role of serotonin 5-HT) and dopamine (DA) receptors in the limb-flick (LF) response elicited by the hallucinogenic ergot LSD and its nonhallucinogenic structural congener lisuride. Pretreatment with either the 5-HT antagonist pizotifen (BC-105) or the DA antagonist haloperidol significantly attenuated LF elicited by either LSD or lisuride. Thus, the LF model failed to differentiate the neuropharmacological actions of LSD and lisuride. Cocaine also prevented LSD- and lisuride-elicited LF simply by reducing the activity of cats (response competition) suggesting the need for caution in interpreting 'antagonism' of the LF response.

References

Jan 1, 1982·Psychopharmacology·F J White, J B Appel
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·F J WhiteJ B Appel
Apr 9, 1981·European Journal of Pharmacology·J L Marini, M H Sheard
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·J L Marini

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Citations

Jul 13, 1984·European Journal of Pharmacology·F Gonzalez-LimaR Medina
Sep 2, 1987·European Journal of Pharmacology·F Gonzalez-LimaC Rivera-Quinones
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·F J White
Jan 1, 1988·Behavioral and Neural Biology·F Gonzalez-LimaR Blanco
Aug 17, 2001·Journal of Immunoassay & Immunochemistry·K NielsenW Kelly
Aug 15, 2012·BMC Emergency Medicine·F Kris Aubrey-Bassler, Nicholas Sowers

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