Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan

Molecular and Cellular Endocrinology
P C GrayW Vale

Abstract

Activin and inhibin research has provided important insight into reproductive physiology as well as many areas involving regulation of cell growth, differentiation and function. Progress in understanding the roles of these hormones in various cell and tissue types has been complimented by novel discoveries at the molecular level that have shed light on ligand/receptor interactions, signaling mechanisms and regulation. While the receptors and signaling pathway for activin are now well characterized, the molecular basis for inhibin action has remained relatively unclear. Here we summarize recent advances in understanding inhibin's mode of action focusing on our recent identification of betaglycan as an inhibin co-receptor capable of mediating inhibin action.

Citations

Dec 5, 2003·Molecular and Cellular Endocrinology·T Rajendra KumarMartin M Matzuk
Oct 9, 2004·Reproductive Biology and Endocrinology : RB&E·Daniel J BernardTony M Plant
Apr 12, 2011·Endocrine Journal·Padmanaban S SureshRie Tsutsumi
Sep 29, 2004·Biological Chemistry·Walter SebaldThomas D Mueller
May 18, 2010·Experimental Cell Research·Rebeca DroguettEnrique Brandan
Jun 13, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Rebeca DroguettEnrique Brandan
Feb 28, 2003·Biology of Reproduction·Joëlle DupontCatherine Taragnat
Sep 29, 2004·Molecular and Cellular Endocrinology·P FlorioF Petraglia
Sep 20, 2015·BMC Biology·Uwe KlammertJoachim Nickel
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Stephen J Winters, Joseph P Moore
Mar 5, 2005·European Journal of Endocrinology·Pasquale FlorioFelice Petraglia
Dec 13, 2018·Physiological Reviews·Enrrico BloiseFernando M Reis
Mar 25, 2008·Molecular Human Reproduction·M C FerreiraF M Reis
Sep 17, 2020·Journal of Developmental Biology·Daniel HalloranAnja Nohe
Apr 10, 2008·The Journal of Biological Chemistry·Yogeshwar MakanjiCraig A Harrison
Dec 16, 2003·The Journal of Biological Chemistry·Gabriela Velasco-LoydenFernando López-Casillas
Aug 28, 2021·Cells·Pasquale EspositoGiacomo Garibotto
Jun 16, 2009·Molecular and Cellular Endocrinology·Ruth M EscalonaGuck T Ooi
Apr 21, 2010·Fertility and Sterility·Daniel J BernardPankaj Lamba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.