Antagonism of acute feeding response to 2-deoxyglucose and 5-thioglucose by GABA antagonists: the relative role of ventromedial and lateral hypothalamus

Pharmacology, Biochemistry, and Behavior
G Lenin KamatchiJ S Bapna

Abstract

The effect of GABA antagonists picrotoxin and bicuculline was studied on hyperphagia caused by 2-DG and 5-TG. The GABA antagonists were administered either SC or into the VMH or LH through stereotaxically implanted chronic cannulae. The peripheral as well as VMH injection antagonised the hyperphagia significantly. In contrast, injection of these agents into the LH failed to produce any effect. These findings show that in a glucoprivic state there might be an increased GABAergic activity in the VMH.

References

Dec 1, 1977·Pharmacology, Biochemistry, and Behavior·J KellyS P Grossman
Jul 1, 1977·Neuropharmacology·L Grandison, A Guidotti
May 28, 1976·Brain Research·M L TappazM Palkovits

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Citations

Mar 1, 1989·Physiology & Behavior·J S FislerG A Bray
Feb 1, 1991·Physiology & Behavior·J L Beverly, R J Martin
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Jul 1, 1989·Brain Research. Brain Research Reviews·R R Matsumoto
Aug 25, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·C Blasi
Jul 17, 2012·Journal of Clinical Biochemistry and Nutrition·Ganesan L Kamatchi, Palaniswami Rathanaswami
Feb 1, 1991·Brain Research·S Tsujii, G A Bray
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L BeverlyL M Arseneau
Mar 1, 1990·The American Journal of Physiology·S Tsujii, G A Bray
Apr 30, 2009·Brain Research·Christine I TureniusB Glenn Stanley

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