PMID: 38474May 25, 1979

Antagonism of apomorphine-induced hyperthermia in MAOI-pretreated rabbits as a sensitive model of neuroleptic activity

Psychopharmacology
B Fjalland

Abstract

Apomorphine induced dose-dependent hyperthermia when applied intravenously to rabbits pretreated with a monoamine oxidase inhibitor. Inhibition of the synthesis of catecholamines (by alpha-MT) did not influence on apomorphine-induced hyperthermia, whereas 5-HT synthesis inhibition (by PCPA) completely abolished the hyperthermic response. Some neuroleptics and a 5-HT receptor blocking agent inhibited the hyperthermia in very low doses. A highly significant correlation was registered between the antagonism of apomorphine hyperthermia of 15 neuroleptics and their clinically useful doses. It is concluded that apomorphine-induced hyperthermia most likely is a result of direct stimulation of dopamine receptors and release of 5-HT, and that abolition of this response represents a very sensitive in-vivo model for neuroleptic substances. Antagonism of apomorphine-induced hyperthermia may be achieved by either dopamine or 5-HT receptor blockade.

References

Dec 1, 1976·Pharmacology, Biochemistry, and Behavior·R M Quock, A Horita
Jun 1, 1975·The Journal of Pharmacy and Pharmacology·C J PycockC D Marsden
Mar 9, 1978·Nature·J E LeysenP M Laduron
Sep 1, 1967·The Journal of Pharmacy and Pharmacology·N E AndénT Hökfelt
Jun 1, 1972·The Journal of Pharmacy and Pharmacology·H F Hill, A Horita
Jan 1, 1972·Psychopharmacologia·M Nymark
May 1, 1970·British Journal of Haematology·B H Doell, P V Hegarty
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Related Concepts

Metazoa
Apokinon
Depression, Chemical
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Reversible Inhibitors of Monoamine Oxidase
Chinchilla Rabbits
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