Antagonism of drug discrimination learning within the conditioned taste aversion procedure

Pharmacology, Biochemistry, and Behavior
G W StevensonA L Riley

Abstract

Animals injected with morphine prior to the presentation of a saccharin-LiCl pairing and the morphine vehicle prior to saccharin alone rapidly acquired the drug discrimination, avoiding saccharin following the administration of morphine and consuming saccharin following its vehicle after only four conditioning trials. Once stimulus control was established, the opiate antagonist naloxone (1 mg/kg) was administered prior to morphine in a test of its ability to antagonize the morphine stimulus. Pretreatment times ranged from 10 to 180 min. Naloxone antagonized the stimulus properties of morphine for all subjects, although there were individual differences in the onset, duration (time course) and degree of antagonism. Together with the rapid acquisition typically reported in this design, the fact that antagonism was demonstrated in the present study suggests that the conditioned taste aversion procedure may be useful in the general assessment of drug discriminations.

References

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Citations

Feb 12, 2008·Psychopharmacology·T U JärbeAlexandros Makriyannis
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S T SmurthwaiteA L Riley
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·P M Melton, A L Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, A L Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Nov 1, 1992·Peptides·G A OlsonA J Kastin
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·G W StevensonAntony L Riley

Related Concepts

Metazoa
Avoidance Learning
Operant Conditioning
Discrimination Learning
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Saccharin Sodium
Taste Perception
Rats, Laboratory

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