Antagonism of ethanol ataxia by intracerebellar nicotine: possible modulation by mouse cerebellar nitric oxide and cGMP

Brain Research Bulletin
S Al-Rejaie, M Saeed Dar

Abstract

We have reported previously that intracerebellar nicotine attenuates ethanol ataxia via nicotinic-cholinergic receptors. We report now that attenuation of ethanol ataxia by intracerebellar nicotine is modulated by cerebellar nitric oxide-guanylyl cyclase (GC) messenger system. Intracerebellar microinfusion of SNP (sodium nitroprusside, a nitric oxide donor; 15, 30, and 60 pg) and SMT (S-methylisothiourea; 70, 140, and 280 fg; an inhibitor of inducible nitric oxide synthase), significantly enhanced and reduced, respectively, intracerebellar nicotine-induced attenuation of ethanol ataxia in a dose-related manner. Similarly, intracerebellar isoliquiritigenin (an activator of GC; 1, 2, and 4 pg) and ODQ (1H [1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one, an inhibitor of GC; 375, 750, and 1500 fg), significantly enhanced and reduced, respectively, intracerebellar nicotine-induced attenuation of ethanol ataxia in a dose-related fashion. These results suggest that the functional interaction between nicotine and ethanol may involve modulation by cerebellar nitric oxide and cGMP. Intracerebellar microinfusion of isoliquiritigenin (4, 8, and 16 pg) in the absence of nicotine significantly attenuated ethanol ataxia dose-dependently indicating ...Continue Reading

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Citations

Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Cassandra A SlaterImad M Damaj
Aug 12, 2008·Brain Research·Anderson Ribeiro-CarvalhoYael Abreu-Villaça
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Salim Al-Rejaie, M Saeed Dar
Jun 7, 2007·Alcoholism, Clinical and Experimental Research·Vera Combs CampbellYousef Tizabi
Apr 23, 2013·Fundamental & Clinical Pharmacology·Manish Manohar AglaweNandkishor Ramdas Kotagale
Aug 12, 2008·Behavioural Pharmacology·Scott D PhilibinJohn C Crabbe
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·M Saeed Dar

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