Abstract
We have reported previously that intracerebellar nicotine attenuates ethanol ataxia via nicotinic-cholinergic receptors. We report now that attenuation of ethanol ataxia by intracerebellar nicotine is modulated by cerebellar nitric oxide-guanylyl cyclase (GC) messenger system. Intracerebellar microinfusion of SNP (sodium nitroprusside, a nitric oxide donor; 15, 30, and 60 pg) and SMT (S-methylisothiourea; 70, 140, and 280 fg; an inhibitor of inducible nitric oxide synthase), significantly enhanced and reduced, respectively, intracerebellar nicotine-induced attenuation of ethanol ataxia in a dose-related manner. Similarly, intracerebellar isoliquiritigenin (an activator of GC; 1, 2, and 4 pg) and ODQ (1H [1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one, an inhibitor of GC; 375, 750, and 1500 fg), significantly enhanced and reduced, respectively, intracerebellar nicotine-induced attenuation of ethanol ataxia in a dose-related fashion. These results suggest that the functional interaction between nicotine and ethanol may involve modulation by cerebellar nitric oxide and cGMP. Intracerebellar microinfusion of isoliquiritigenin (4, 8, and 16 pg) in the absence of nicotine significantly attenuated ethanol ataxia dose-dependently indicating ...Continue Reading
References
Jan 1, 1992·Psychopharmacology·E D Levin
Mar 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·D M Warburton
Jan 1, 1989·Life Sciences·M Clark, M S Dar
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·A C CollinsM J Marks
Oct 3, 1983·Life Sciences·M S DarW R Wooles
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jul 14, 1995·Neuroscience Letters·Y KamisakiT Itoh
Oct 1, 1993·Analytical Biochemistry·T P MiskoM G Currie
Jan 1, 1995·Brain Research Bulletin·J Anwer, M S Dar
Jul 1, 1994·The American Journal of Psychiatry·M A SchuckitT Smith
Jan 1, 1994·Life Sciences·J E FlesherJ J Frost
Jan 1, 1993·Brain Research Bulletin·M S DarE R Bowman
Sep 1, 1996·Alcoholism, Clinical and Experimental Research·A C CollinsA E Bullock
May 6, 1997·Neuroreport·J ChenL Tang
Sep 18, 1997·Neuroscience Research·S HamidJ D Stephenson
Jun 10, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P BienkowskiW Kostowski
Dec 10, 1998·British Journal of Pharmacology·E FedeleM Raiteri
Jan 23, 1999·Intensive Care Medicine·C Weissman
Mar 13, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·W DyrW Kostowski
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·X YangG R Breese
Jul 16, 1999·Neurochemistry International·T NarahashiK Nagata
Jul 16, 1999·Neurochemistry International·X YangG R Breese
Jan 8, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·J T HaysM C Fiore
Nov 15, 2000·Neuropharmacology·N A Hartell
Aug 1, 1995·Behavioural Pharmacology·W. DanyszC.G. Parsons
Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Fernández-CancioS Imperial
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Amir H Rezvani, Edward D Levin
Sep 5, 2003·Psychopharmacology·Elisabeth Wazlawik, Gina Struffaldi Morato
Oct 16, 2003·Nitric Oxide : Biology and Chemistry·Andreas DaiberThomas Munzel
Feb 26, 2004·Neuroscience·L A C RenoR P Markus
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mario CartaC Fernando Valenzuela
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Nassima Ait-DaoudBankole A Johnson
Sep 1, 1998·Trends in Cognitive Sciences·J Voogd, M Glickstein
Citations
Dec 29, 2007·Amino Acids·R SuenagaM Furuse
Jan 26, 2008·Amino Acids·R SuenagaM Furuse
Sep 21, 2011·Neurotoxicity Research·Laura L HurleyYousef Tizabi
Oct 29, 2013·Nature Neuroscience·Joshua S KaplanDavid J Rossi
Mar 7, 2012·Neurochemistry International·Zoltán SerfőzőFerenc Erdődi
Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Cassandra A SlaterImad M Damaj
Aug 12, 2008·Brain Research·Anderson Ribeiro-CarvalhoYael Abreu-Villaça
Dec 17, 2008·Alcoholism, Clinical and Experimental Research·Guichu Li, Abdel A Abdel-Rahman
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Salim Al-Rejaie, M Saeed Dar
Jun 7, 2007·Alcoholism, Clinical and Experimental Research·Vera Combs CampbellYousef Tizabi
Nov 21, 2012·Alcoholism, Clinical and Experimental Research·Nathan SantosSelena E Bartlett
Apr 23, 2013·Fundamental & Clinical Pharmacology·Manish Manohar AglaweNandkishor Ramdas Kotagale
Oct 27, 2010·Behavioural Brain Research·Najla TaslimM Saeed Dar
Jul 19, 2016·Alcoholism, Clinical and Experimental Research·Joshua S KaplanDavid J Rossi
Sep 25, 2008·Neuroscience·N TaslimM Saeed Dar
Aug 12, 2008·Behavioural Pharmacology·Scott D PhilibinJohn C Crabbe
Aug 21, 2013·The American Journal on Addictions·Roberto NocenteMauro Ceccanti
Jan 13, 2015·The Cerebellum·M Saeed Dar
Dec 15, 2010·Alcoholism, Clinical and Experimental Research·Najla Taslim, M Saeed Dar
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·M Saeed Dar
Dec 15, 2018·Chemistry, an Asian Journal·Denan WangRajendra Rathore
Jun 12, 2021·Scientific Reports·Athareh PabarjaTahereh Haghpanah