PMID: 11312897Apr 21, 2001Paper

Antagonism of free-radical-induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U937 monocytic cells

Journal of Agricultural and Food Chemistry
C C KuoWenchang Chiang

Abstract

The goal of our current research was to investigate the antioxidative effects of methanolic extracts from different parts of adlay seed and their antiproliferative activity in malignant human cells. The methanolic extracts from different parts of adlay seeds were from the hull (AHM), testa (ATM), bran (ABM), and polished adlay (PAM). AHM exhibited greater capacity to scavenge superoxide anion radicals in the PMS-NADH system than ATM, ABM, or PAM. The scavenging capacities of AHM and ATM on hydrogen peroxides were about 20% at a dose of 250 microg/mL. Using the method of deoxyribose degradation to assess damage caused by hydroxyl radicals, AHM was found to inhibit damage in deoxyribose at a higher concentration. However, ATM, ABM, and PAM exhibited prooxidative activity at the same concentration. The inhibitory effect on enzymatic oxidation of xanthine to uric acid was found to follow the order AHM > ATM =. ABM. However, PAM was inactive. All test samples were positive for inhibition of TPA-induced free radical formation on neutrophil-like leukocytes and were found to follow the order AHM > ATM > ABM > PAM. When human histolytic lymphoma U937 monocytic cells were exposed to tert-butyl hydroperoxide, AHM protected the cells again...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·T Yoshikawa
Mar 1, 1988·Biochemical Pharmacology·J Robak, R J Gryglewski
Apr 1, 1984·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·S TodaY Takino
Jan 1, 1993·Critical Reviews in Toxicology·J P Kehrer
Feb 15, 1996·Biochimica Et Biophysica Acta·L M Henderson, J B Chappel
Jun 1, 1996·The American Journal of Clinical Nutrition·R A Jacob, B J Burri
Dec 31, 1998·Free Radical Biology & Medicine·M NardiniC Scaccini

❮ Previous
Next ❯

Citations

May 13, 2011·Journal of Agricultural and Food Chemistry·Huang-Hui ChenChing-Chuan Kuo
May 8, 2013·Journal of Agricultural and Food Chemistry·Lifeng WangRui Hai Liu
Aug 4, 2005·Journal of Toxicology and Environmental Health. Part a·Hui-Ping TzengShing-Hwa Liu
Feb 5, 2014·Journal of Food Science and Technology·Jiradej ManosroiAranya Manosroi
Apr 7, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Luciana NasoPatricia Williams
Mar 15, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Luciana G NasoPatricia A M Williams
Sep 23, 2014·International Journal of Molecular Sciences·Huey-Chun HuangTsong-Min Chang
Apr 10, 2014·Journal of Traditional and Complementary Medicine·Rong-Sen YangShing-Hwa Liu
Feb 4, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Evelina G FerrerPatricia A M Williams
Jan 11, 2011·Journal of the Science of Food and Agriculture·Sing-Chung LiChun-Kuang Shih
Apr 1, 2011·Journal of the Science of Food and Agriculture·Fei YuChang-Xiao Liu
Jun 23, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chun-Kuang ShihMin-Liang Kuo
Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B W HuangW Chiang
Mar 12, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Yi LeeYueh-Hsiung Kuo
Jun 26, 2008·American Journal of Physiology. Endocrinology and Metabolism·Shih-Min HsiaPaulus S Wang
Jul 30, 2019·Frontiers in Pharmacology·Weixiao AnShousong Cao
Nov 8, 2017·BMC Complementary and Alternative Medicine·Eun Suk SonSe-Hee Kim
Nov 16, 2019·BMC Complementary and Alternative Medicine·Eun Suk SonJeong-Woong Park
Jul 23, 2020·Journal of Traditional and Complementary Medicine·Hui-Ching LinTzong-Fu Kuo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis