Antagonism of noradrenaline and histamine by desipramine in the isolated artery of the rabbit ear

British Journal of Pharmacology
M W McCulloch, D F Story


1. The effects of desipramine (DMI) were examined on the vasoconstrictor responses of the isolated perfused artery of the rabbit ear to noradrenaline (NA) and to histamine. Innervated and sympathetically denervated arteries were used.2. In innervated arteries, DMI in concentrations of 1 x 10(-8) to 1 x 10(-7)M enhanced the responses to NA; higher concentrations reduced the responses. In sympathetically denervated arteries, DMI caused only reduction of the responses to NA.3. Responses to histamine were reduced by DMI in both innervated and denervated arteries. DMI was considerably more potent as an antagonist of histamine than of noradrenaline.4. The reduction by DMI of the responses to NA and histamine in both innervated and denervated arteries was associated with a parallel shift to the right of the concentration-response curves of the agonist and a depression of the maximal response. These effects of DMI were reversible.5. Analysis of the data by the method of Arunlakshana & Schild (1959) showed the following: the antagonism of the action of NA by DMI on denervated arteries fulfilled the requirements for competitive antagonism; antagonism of the action of NA on innervated arteries was not competitive; antagonism of the action...Continue Reading


Apr 15, 1967·Experientia·R K Turker, P A Khairallah
Oct 1, 1967·The Journal of Pharmacy and Pharmacology·P Hrdina, S Garattini
Oct 1, 1970·The Journal of Pharmacy and Pharmacology·A B Glover, M W McCulloch
Sep 1, 1969·British Journal of Pharmacology·J R BassettM Story
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jan 1, 1965·The Journal of Pharmacy and Pharmacology·L L IVERSEN
Dec 1, 1966·British Journal of Pharmacology and Chemotherapy·I S De La LandeJ G Waterson
Sep 1, 1947·British Journal of Pharmacology and Chemotherapy·H O SCHILD

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