PMID: 4085627Nov 1, 1985

Antagonism of parmidin to kinin effects

Farmakologiia i toksikologiia
G Ia ShvartsR D Siubaev

Abstract

Parmidin in 10(-9)-10(-5) g/ml concentrations displays specific and competitive antagonism to spasmogenic effects of bradykinin and methionyl-lysil-bradykinin on isolated segments of the guinea pig ileum, rat uteral cornua, cat jejunum and spiral strips of the rabbit aorta. Its antagonism to the spasmogenic effect of lysil-bradykinin is of both competitive and non-competitive character. In rats parmidin in 100 mg/kg dose decreased the paw edema, induced by kinins but it did not influence the similar effect of histamine and that of prostaglandin F2.

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Bradykinin, Met-Lys-
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