Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol

British Journal of Pharmacology
A BennettD E Wilson

Abstract

1 The effects of SC-19220, sodium meclofenamate, indomethacin or trimethoquinol were studied on contractions of the rat stomach longitudinal muscle to prostaglandin D2 (PGD2), PGE2, PGF2 alpha, PGH2, epoxymethano PGH2 analogues, PGI2, 6-keto-PGF1 alpha, 6,15-diketo-PGF1 alpha and thromboxane B2. All the drugs reduced contractions to all the prostanoids, but the degree of reduction differed widely. Selectivity of blockade was assessed by comparison with acetylcholine (ACh). 2 With SC-19220 5 micrograms/ml the effect on thromboxane B2, PGD2 or PGH2 and its epoxymethano analogues was not significantly different from the small effect on ACh, but the other prostanoids were blocked to greater extents. 3 The effect of the cyclo-oxygenase inhibitor sodium meclofenamate, 1 or 2 micrograms/ml, on 6,15-diketo-PGF1 alpha or thromboxane B2 was similar to the small antagonism of ACh, whereas the other prostanoids were blocked to greater extents. Indomethacin, 1 microgram/ml, also reduced contractions to the prostanoids, but antagonism of the PGH2 epoxymethano analogues was considerably less than with meclofenamate. 4 The beta-adrenoceptor stimulant trimethoquinol, 50 ng/ml, was the most potent prostanoid antagonist tested; all the prostanoid...Continue Reading

References

Dec 1, 1979·The Journal of Pharmacy and Pharmacology·C J Hanna, P Eyre
Nov 1, 1979·British Journal of Clinical Pharmacology·G J Sanger, A Bennett
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, H Juan
Feb 1, 1972·European Journal of Pharmacology·L SorrentinoM Di Rosa
Aug 1, 1971·British Journal of Pharmacology·A Bennett, J Posner
Nov 1, 1966·Canadian Journal of Physiology and Pharmacology·F Coceani, L S Wolfe
Oct 1, 1980·The Journal of Pharmacy and Pharmacology·G J Sanger, A Bennett
Jun 1, 1980·Prostaglandins·P J Gardiner, H O Collier
Mar 1, 1980·British Journal of Pharmacology·A BennettG J Sanger

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