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Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model

Scientific Reports

Nov 13, 2019

Benjamin A SatterfieldChad E Mire

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Abstract

Nipah virus (NiV) is a pathogenic paramyxovirus and zoononis with very high human fatality rates. Previous protein over-expression studies have shown that various mutations to the common N-terminal STAT1-binding motif of the NiV P, V, and W proteins affected the STAT1-binding ability of...read more

Mentioned in this Paper

Gene Deletion
Metabolic Inhibition
Interferons
Binding Protein
STAT1 protein
Paramyxovirus, NOS
Recognition (Psychology)
Pathogenesis
Nipah Virus
Molecular_function
1
2
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Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

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Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model

Scientific Reports

Nov 13, 2019

Benjamin A SatterfieldChad E Mire

PMID: 31723221

DOI: 10.1038/s41598-019-53037-0

Abstract

Nipah virus (NiV) is a pathogenic paramyxovirus and zoononis with very high human fatality rates. Previous protein over-expression studies have shown that various mutations to the common N-terminal STAT1-binding motif of the NiV P, V, and W proteins affected the STAT1-binding ability of...read more

Mentioned in this Paper

Gene Deletion
Metabolic Inhibition
Interferons
Binding Protein
STAT1 protein
1
2

Related Papers

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