Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity

Molecular Plant
Haitao CuiJane E Parker

Abstract

In plant immunity, pathogen-activated intracellular nucleotide binding/leucine rich repeat (NLR) receptors mobilize disease resistance pathways, but the downstream signaling mechanisms remain obscure. Enhanced disease susceptibility 1 (EDS1) controls transcriptional reprogramming in resistance triggered by Toll-Interleukin1-Receptor domain (TIR)-family NLRs (TNLs). Transcriptional induction of the salicylic acid (SA) hormone defense sector provides one crucial barrier against biotrophic pathogens. Here, we present genetic and molecular evidence that in Arabidopsis an EDS1 complex with its partner PAD4 inhibits MYC2, a master regulator of SA-antagonizing jasmonic acid (JA) hormone pathways. In the TNL immune response, EDS1/PAD4 interference with MYC2 boosts the SA defense sector independently of EDS1-induced SA synthesis, thereby effectively blocking actions of a potent bacterial JA mimic, coronatine (COR). We show that antagonism of MYC2 occurs after COR has been sensed inside the nucleús but before or coincident with MYC2 binding to a target promoter, pANAC019. The stable interaction of PAD4 with MYC2 in planta is competed by EDS1-PAD4 complexes. However, suppression of MYC2-promoted genes requires EDS1 together with PAD4, poi...Continue Reading

Citations

Nov 9, 2019·Molecular Plant-microbe Interactions : MPMI·Joram Andreas DongusJane E Parker
Dec 27, 2019·Molecular Plant-microbe Interactions : MPMI·Matthew NeubauerRoger W Innes
May 13, 2020·Annual Review of Phytopathology·Dmitry LapinJane E Parker
Jul 22, 2019·Nature Communications·Yongliang ZhangSavithramma P Dinesh-Kumar
Sep 7, 2019·International Journal of Molecular Sciences·Igor PokotyloEric Ruelland
Jan 1, 2020·Plant Direct·Christopher J TillMichael J Holdsworth
Oct 14, 2020·Molecular Plant-microbe Interactions : MPMI·You Lu, Kenichi Tsuda
Sep 17, 2020·Journal of Experimental Botany·Xiaoxiao LiuZhiyong Gao
Nov 15, 2020·Journal of Experimental Botany·Marco ZarattiniMathilde Fagard
Feb 23, 2021·The Plant Journal : for Cell and Molecular Biology·Niels AertsSaskia C M Van Wees
Oct 15, 2020·International Journal of Molecular Sciences·Aarti GuptaLam-Son Phan Tran
Sep 10, 2020·Plant Science : an International Journal of Experimental Plant Biology·Fernanda ValandroAlexandro Cagliari
May 1, 2021·Current Opinion in Plant Biology·Joram A Dongus, Jane E Parker
Oct 2, 2021·Physiologia Plantarum·Janesh Kumar GautamAshis Kumar Nandi

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