Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog

British Journal of Pharmacology
M J DalyR Stables

Abstract

1 The new H2-receptor antagonist, ranitidine, has been compared with cimetidine as an inhibitor of gastric acid secretion in the anaesthetized dog. 2 Both ranitidine and cimetidine given intravenously inhibited histamine-induced gastric secretion in a dose-related manner. Ranitidine was 4.2 times more potent than cimetidine when given as an intravenous infusion and 9.6 times more potent as an intravenous bolus dose. 3 In a separate series of experiments, ranitidine was compared with cimetidine as an antagonist of vasodepressor responses to histamine. Mepyramine alone displaced the histamine dose-response curve to the right. After a maximally effective dose of mepyramine, further displacement could be achieved with ranitidine and cimetidine, ranitidine being 19.2 times more potent than cimetidine. 4 Ranitidine alone has no effect on vasodepressor response curves to histamine, acetylcholine or (-)-isoprenaline or on vasopressor response curves to phenylephrine. 5 These results indicate that displacement of the histamine dose-response curve after mepyramine blockade by ranitidine and cimetidine is due to selective H2-receptor antagonism.

References

Jan 1, 1981·British Journal of Pharmacology·M J DalyR Stables
Apr 3, 1958·The Journal of Physiology·J W BLACKA N SMITH
Dec 31, 1910·The Journal of Physiology·H H Dale, P P Laidlaw
Oct 20, 1911·The Journal of Physiology·H H Dale, P P Laidlaw

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Citations

May 1, 1981·Digestive Diseases and Sciences·K M WalusE D Jacobson
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H W BreuerG Arnold
Mar 27, 2002·Biological & Pharmaceutical Bulletin·Hiroki ItohMasaharu Takeyama
Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·J DawsonR Cockel
Aug 1, 1985·The Journal of Pediatrics·J L BlumerM D Reed
Dec 1, 1983·Drug Intelligence & Clinical Pharmacy·T S Gaginella, J H Bauman

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