Antagonist-precipitated and discontinuation-induced withdrawal in morphine-dependent rhesus monkeys.

Psychopharmacology
G L BeckerC P France

Abstract

Upon discontinuation of chronic opioid treatment, withdrawal typically peaks in 1-3 days and decreases markedly within 1 week; however, persistent physiological changes have been reported long after other signs have waned. The goal of this study was to compare the discriminative stimulus, directly observable signs, and physiological effects of withdrawal in morphine-treated monkeys. Monkeys received 5.6 mg/kg/12 h morphine and discriminated 0.0178 mg/kg naltrexone while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Drug discrimination, behavioral observation, and telemetry were used to monitor the emergence of withdrawal, as well as any persistent changes, following discontinuation of morphine treatment. Naltrexone dose (0.001-0.032 mg/kg, s.c.) was positively related with indices of withdrawal. In the discrimination study, monkeys responded on the naltrexone lever 1-5 days following discontinuation of treatment; thereafter, they responded exclusively on the saline lever. After discontinuation of morphine, the frequency of observable signs peaked within 2-3 days and most were not significantly increased after 5 days. In contrast, increased heart rate and body temperature persisted for 14 days, returni...Continue Reading

References

Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·D B NewlinL J Cheskin
Nov 1, 1985·Archives of General Psychiatry·D R JasinskiT R Kocher
Mar 30, 1999·European Journal of Pharmacology·R ChanJ White
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Stacy L Sell, Charles P France
Oct 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lance R McMahonCharles P France
Feb 12, 2005·Behavioural Pharmacology·S L SellC P France
Jan 16, 2007·The Journal of Pharmacology and Experimental Therapeutics·Jun-Xu LiCharles P France

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Citations

Sep 28, 2010·Journal of Pharmacological and Toxicological Methods·Paul MoserMark Duxon
Oct 2, 2009·Peptides·Richard J Bodnar
Apr 5, 2013·Journal of the Experimental Analysis of Behavior·Amy K EppolitoLisa R Gerak
Apr 4, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joanne K MarcarioShilpa J Buch
Jul 24, 2015·Psychopharmacology·L R GerakC P France
Mar 5, 2016·The Journal of Pharmacology and Experimental Therapeutics·L R Gerak, C P France
May 5, 2011·Journal of the Experimental Analysis of Behavior·Tammy Wade-GaluskaGail Winger
Nov 22, 2019·The Journal of Pharmacology and Experimental Therapeutics·David R MaguirePeter Flynn

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