PMID: 2502027Jul 1, 1989Paper

Antagonist to GH-releasing factor inhibits growth and renal Pi reabsorption in immature rats

The American Journal of Physiology
S E MulroneyA Haramati

Abstract

Compared with adult rats, the immature rat has an enhanced tubular capacity for phosphate reabsorption, which presumably facilitates the growth process. Since the main driving force for growth is thought to be the pulsatile release of growth hormone, we examined the possibility that the adaptation in phosphate handling by the immature kidney is promoted by growth hormone (GH). To address this issue, we used a synthetic peptide antagonist to GH-releasing factor (GRF-AN) that we have shown blocks episodic GH secretion, and attenuates somatic growth. Immature male Wistar rats (4-5 wk of age) were catheterized with Silastic jugular cannulas and placed in metabolic cages. The rats were injected intravenously with either saline or GRF-AN (100 micrograms/kg) twice daily for 4 days. On the 4th day, they were prepared for renal clearance experiments to assess the maximum capacity for phosphate transport (TmPi). In animals treated with GRF-AN, there was an attenuated gain in body weight over 4 days of treatment (5 +/- 2 vs. 23 +/- 2% in saline controls, P less than 0.01). The suppressed growth was associated with a doubling of daily urinary phosphate excretion, and a reduction in the TmPi (3.3 +/- 0.1 vs. 4.6 +/- 0.3 mumol/ml in controls...Continue Reading

Citations

Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C WodaA Haramati
Dec 3, 2003·American Journal of Physiology. Renal Physiology·Susan E MulroneyMoshe Levi
Jun 26, 2003·American Journal of Physiology. Renal Physiology·Ka-Yin K MokSusan E Mulroney
Oct 4, 2000·Physiological Reviews·H MurerJ Biber
Mar 5, 2004·American Journal of Physiology. Renal Physiology·Craig B WodaSusan E Mulroney

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