Antagonistic Actions of FPA and IBM2 Regulate Transcript Processing from Genes Containing Heterochromatin

Plant Physiology
Aurélie DeremetzNicolas Bouché

Abstract

Repressive epigenetic marks, such as DNA and histone methylation, are sometimes located within introns. In Arabidopsis (Arabidopsis thaliana), INCREASE IN BONSAI METHYLATION2 (IBM2), an RNA-binding protein containing a bromo-adjacent homology domain, is required to process functional transcript isoforms of genes carrying intronic heterochromatin. In a genetic screen for suppressors of the ibm2 mutation, we identified FPA, an RNA-binding protein that promotes use of proximal polyadenylation sites in genes targeted by IBM2, including IBM1 encoding an essential H3K9 histone demethylase and the disease resistance gene RECOGNITION OF PERONOSPORA PARASITICA7 Both IBM2 and FPA are involved in the processing of their common mRNA targets: Transcription of IBM2 target genes is restored when FPA is mutated in ibm2 and impaired in transgenic plants overexpressing FPA By contrast, transposons targeted by IBM2 and localized outside introns are not under this antagonistic control. The DNA methylation patterns of some genes and transposons are modified in fpa plants, including the large intron of IBM1, but these changes are rather limited and reversed when the mutant is complemented, indicating that FPA has a restricted role in mediating silen...Continue Reading

Citations

Jan 8, 2020·The Plant Journal : for Cell and Molecular Biology·Manohar ChakrabartiArthur G Hunt
Sep 18, 2020·Nucleic Acids Research·Guillaume HummelLaurence Drouard
Jul 28, 2020·Plants·David Zalabák, Yoshihisa Ikeda
Sep 26, 2020·Frontiers in Genetics·Jian ZhangCheng-Guo Duan
Jan 14, 2021·Journal of Integrative Plant Biology·Yi-Zhe ZhangCheng-Guo Duan

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