PMID: 6108937Jan 1, 1980Paper

Antagonistic actions of MIF-I on the hypothermia and hypomotility induced by beta-endorphin or morphine

The International Journal of Neuroscience
S YehudaD H Coy

Abstract

Recently it has been suggested that MIF-I can act as an opiate antagonist for analgesia. Therefore, rats kept at 4 degrees C were pretreated with MIF-I in an attempt to extend the observation to a nonanalgesic opiate effect by determining any blockade of the thermal response to beta-endorphin and morphine. MIF-I, at an ip dose of 1.0 mg/kg, was found to block the thermal responses to beta-endorphin injected ip at doses of 0.1 and 1.0 mg/kg. A lower dose (0.1 mg/kg, ip) of MIF-I, or naloxone (10 mg/kg), was also able to block the thermal effects of 30 and 60 mg/kg doses of morphine. However, an ip dose of 1.0 mg/kg MIF-I potentiated the hypothermic effects of morphine but, like naloxone, reduced the magnitude of the decrease in the level of motor activity induced by beta-endorphin or by morphine. The results of this study demonstrate a nonanalgesic situation in which MIF-I can act as an antagonist of opiate effects after peripheral injection.

References

Jul 30, 1979·Life Sciences·A J KastinD H Coy
Dec 1, 1979·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Nov 5, 1979·Life Sciences·J SawynokF S LaBella
Dec 1, 1979·Pharmacology, Biochemistry, and Behavior·B M KingR D Olson
Sep 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·S Yehuda, R J Wurtman

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Citations

Mar 1, 1983·Physiology & Behavior·J E MorleyU S Seal
Dec 1, 1985·Physiology & Behavior·E D PlotkaU S Seal
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
May 1, 1989·Pharmacology, Biochemistry, and Behavior·A J KastinD S Schwartzenburg
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·B B GorzalkaS A Tanco
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·S Yehuda, A J Kastin
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·G W ReedR D Olson
Jan 1, 1983·Pharmacology & Therapeutics·W G Clark, J M Lipton
Dec 1, 1981·Brain Research Bulletin·M G LucianoD H Coy
Jan 1, 1995·Fundamental & Clinical Pharmacology·F Cesselin
Jan 1, 1981·Peptides·G A OlsonD H Coy
Jan 1, 2000·Nutritional Neuroscience·M B YoudimS Yehuda
Nov 9, 2007·Peptides·Weihong Pan, Abba J Kastin

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