Sep 18, 2004

Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens

FEMS Microbiology Reviews
Alain L Servin

Abstract

The gastrointestinal tract is a complex ecosystem that associates a resident microbiota and cells of various phenotypes lining the epithelial wall expressing complex metabolic activities. The resident microbiota in the digestive tract is a heterogeneous microbial ecosystem containing up to 1 x 10(14) colony-forming units (CFUs) of bacteria. The intestinal microbiota plays an important role in normal gut function and maintaining host health. The host is protected from attack by potentially harmful microbial microorganisms by the physical and chemical barriers created by the gastrointestinal epithelium. The cells lining the gastrointestinal epithelium and the resident microbiota are two partners that properly and/or synergistically function to promote an efficient host system of defence. The gastrointestinal cells that make up the epithelium, provide a physical barrier that protects the host against the unwanted intrusion of microorganisms into the gastrointestinal microbiota, and against the penetration of harmful microorganisms which usurp the cellular molecules and signalling pathways of the host to become pathogenic. One of the basic physiological functions of the resident microbiota is that it functions as a microbial barrie...Continue Reading

Mentioned in this Paper

Giardia lamblia
Microorganism
Metabolic Process, Cellular
Interleukins
Endoscopy (Procedure)
Immune Response
Pathogenic Aspects
Salmonella enteritidis
Biochemical Pathway
Immune System

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