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Antagonistic activity of analogs of luteinizing hormone-releasing hormone (LH-RH) in vitro

Molecular and Cellular Endocrinology

Jan 1, 1976

David H CoyA V Schally

PMID: 782958

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Abstract

The ability of eighteen analogs of LH-RH to inhibit LH-RH-induced LH release was tested in primary cultures of rat anterior pituitary cells. [Des-His2]LH-RH, [Des-His2, D-Leu6]LH-RH and [Des-His2, D-Phe6]LH-RH inhibited 50% of LH-RH-induced LH release at molar ratios (MR50S) of 3000, 50...read more

Mentioned in this Paper

Analogs & derivatives
Recombinant Gonadorelin
Analog
Gonadorelin Hydrochloride
GNRH1 gene
Luteozyman
Structure-Activity Relationship
DLD gene
Phenylalanine, D
HTN3 gene
Paper Details
References
  • References15
  • Citations3
12

Antagonistic activity of analogs of luteinizing hormone-releasing hormone (LH-RH) in vitro

Molecular and Cellular Endocrinology

Jan 1, 1976

David H CoyA V Schally

PMID: 782958

DOI:

Abstract

The ability of eighteen analogs of LH-RH to inhibit LH-RH-induced LH release was tested in primary cultures of rat anterior pituitary cells. [Des-His2]LH-RH, [Des-His2, D-Leu6]LH-RH and [Des-His2, D-Phe6]LH-RH inhibited 50% of LH-RH-induced LH release at molar ratios (MR50S) of 3000, 50...read more

Mentioned in this Paper

Analogs & derivatives
Recombinant Gonadorelin
Analog
Gonadorelin Hydrochloride
GNRH1 gene

Related Papers

Paper Details
References
  • References15
  • Citations3
12

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