Antagonistic effect of IL1 variants in periodontitis and external apical root resorption: Evidence from a literature review

Archives of Oral Biology
Sónia Alves PereiraHenriqueta Coimbra Silva

Abstract

External apical root resorption (EARR) induced by orthodontic treatment and chronic periodontitis (CP) are complex phenotypes dependent on the interaction of multiple genetic and non-genetic risk factors. Apart from different environmental triggers, these phenotypes are caused by antagonistic biological mechanisms involving local immunoinflammatory reaction and alveolar bone metabolism, for which IL1 have a prominent role. Whereas EARR benefits from bone remodelling, CP is characterized by osteolytic damaged. Our aim was to verify if these two phenotypes have opposite genetic profiles, considering the most frequently analysed polymorphisms for both diseases. A review of the literature was performed searching for the association of rs1800587 from Interleukin-1 alpha (IL1A) gene and rs1143634 from interleukin-1 beta (IL1B) gene with EARR and CP. The electronic search included MEDLINE/PubMed, EBSCOhost, Cochrane and Web of Science databases. Twenty four articles met the inclusion and exclusion criteria. For IL1B polymorphism, two out of seven studies found a significant statistical association between EARR and CC genotype, whether for CP, there were eighth out of fifteen references describing a statistically significant associatio...Continue Reading

Citations

Apr 11, 2019·Brazilian Dental Journal·Sidinéia Feitoza de JesusLéa Assed Bezerra da Silva
Oct 4, 2019·International Endodontic Journal·A De RossiS Y Fukada

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