PMID: 2484523Jan 1, 1988Paper

Antagonistic effect of selenite on tumor promoter induced cell proliferation in cultures of rat tongue epithelium

Biological Trace Element Research
D Arenholt-BindslevA Jepsen

Abstract

In cultures of rat tongue epithelial cells, cell proliferation following incubation with different doses of the potent tumor promoter TPA has been studied by using a stathmokinetic method counting colchicine arrested metaphases. It was demonstrated that 24 h incubation with concentrations higher than 5 ng TPA/mL medium caused inhibition, whereas below 5 ng TPA/mL medium caused stimulation of the mitotic activity reaching a maximum around 30 h from the start of the incubation period. Based on the evidence of the anticarcinogenic effect of selenium in several animal models, experiments have been performed elucidating the influence of an atoxic dose (1/1.000.000M) of selenite on the observed TPA-induced cell proliferation. Our results indicate that addition to the culture medium of an atoxic dose of selenite, not affecting the mitotic activity of control cultures, inhibits the TPA-induced stimulation of cell proliferation.

References

Apr 1, 1983·Environmental Health Perspectives·T J Slaga
Jul 1, 1983·The Journal of Investigative Dermatology·L M Milstone
Jan 1, 1980·Experimental Cell Research·A JepsenJ H Lillie
Jan 1, 1981·Differentiation; Research in Biological Diversity·C DelescluseM Pruniéras
Nov 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·R A Sunde, W G Hoekstra

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Citations

Jan 1, 1995·Archives of Dermatological Research·P CelerierB Dreno
May 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·M A Tariq, I L Preiss

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