Abstract
A bacteriocin-like substance, active against strains of Clostridium botulinum type E, is produced by certain nontoxic organisms whose biochemical properties and morphological characteristics are similar to type E. The substance, for which the name "boticin E" is proposed, is bacteriolytic for vegetative cells and bacteriostatic for spores of type E. Its spectrum of activity is somewhat strain-specific. Of the clostridial species tested, only C. botulinum type E and, to a lesser extent, C. perfringens and C. acetobutylicum, but not C. botulinum types A, B, or F, are sensitive. Irreversibly resistant variants originating from both vegetative cells and spores of certain strains were obtained. The active substance is heat-stable and dialyzable, and is not inactivated by chloroform but is digested by trypsin. Ethyl alcohol and acetone precipitates are fully active, whereas trichloroacetic acid precipitates are only partially active. Other nontoxic organisms producing similar antagonistic substances are discussed.
References
Aug 1, 1965·The Journal of Applied Bacteriology·G HobbsJ M Shewan
Jun 1, 1955·Japanese Journal of Medical Science & Biology·G SAKAGUCHI, Y TOHYAMA
Oct 1, 1956·Journal of Bacteriology·J T DUFFA YARINSKY
Jun 1, 1957·Journal of General Microbiology·G IVANOVICS, L ALFOLDI
Oct 1, 1958·Journal of General Microbiology·R BEN-GURION, I HERTMAN
Mar 1, 1961·The Biochemical Journal·I B HOLLAND
Feb 1, 1964·Journal of Bacteriology·J V BETZ, K E ANDERSON
Nov 1, 1964·Journal of Bacteriology·R JOHNSTOND KAUTTER
Mar 1, 1965·Bacteriological Reviews·P REEVES
Aug 1, 1959·Journal of General Microbiology·G IVANOVICSE NAGY
Apr 4, 1941·Science·M P Starr
Citations
Dec 1, 1970·Journal of Bacteriology·G W BrownH Sugiyama
Sep 1, 1976·Bacteriological Reviews·J R TaggL W Wannamaker
Nov 1, 1984·Applied and Environmental Microbiology·M S StromF T Poysky
May 1, 1968·Journal of Bacteriology·T L BottH Sugiyama
Oct 1, 1970·Journal of Bacteriology·J S Ellison, J A Kautter
Jul 1, 1971·Journal of Bacteriology·K L AnastasioH Sugiyama
Jul 1, 1967·Applied Microbiology·P J PaceH J Wisniewski
Jun 1, 1988·Applied and Environmental Microbiology·M W EklundM S Strom
Nov 1, 1993·Applied and Environmental Microbiology·Y ZhouE A Johnson
Sep 18, 2012·Journal of Bacteriology·Dana GebhartDean Scholl
Feb 1, 1974·Applied Microbiology·P L Kwan, J S Lee
Oct 1, 1971·Journal of Bacteriology·J S EllisonW A Daniel
Jan 13, 2004·Journal of Clinical Microbiology·Jean-Philippe CarlierFrancine Mory
May 1, 1969·Journal of Bacteriology·H M SolomonT Lilly
Feb 1, 1971·Applied Microbiology·H M SolomonT Lilly
Apr 1, 1980·Applied and Environmental Microbiology·H H Huss
Nov 11, 1975·Applied Microbiology·A AnellisV R Dowell
Aug 1, 1987·Applied and Environmental Microbiology·W F SonnabendT Krech
Aug 1, 1997·Journal of Clinical Microbiology·K YamakawaS Nakamura
Nov 1, 1969·Applied Microbiology·G A Houghtby, C A Kaysner
May 1, 1990·International Journal of Food Microbiology·D A BakerV Razavilar